Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 693065..693733 Replicon chromosome
Accession NZ_AP024956
Organism Paraburkholderia terrae strain KU-64

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PTKU64_RS19080 Protein ID WP_091776683.1
Coordinates 693392..693733 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTKU64_RS19075 Protein ID WP_086914644.1
Coordinates 693065..693376 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTKU64_RS19065 (PTKU64_37620) 689418..690701 + 1284 WP_042306565.1 4-aminobutyrate--2-oxoglutarate transaminase -
PTKU64_RS19070 (PTKU64_37630) 691504..692970 + 1467 WP_042316640.1 NAD-dependent succinate-semialdehyde dehydrogenase -
PTKU64_RS19075 (PTKU64_37640) 693065..693376 - 312 WP_086914644.1 helix-turn-helix domain-containing protein Antitoxin
PTKU64_RS19080 (PTKU64_37650) 693392..693733 - 342 WP_091776683.1 toxin Toxin
PTKU64_RS19085 (PTKU64_37660) 694003..694977 - 975 WP_229514798.1 lipoyl synthase -
PTKU64_RS19090 (PTKU64_37670) 694980..696092 - 1113 WP_229514799.1 acetoin dehydrogenase dihydrolipoyllysine-residue acetyltransferase subunit -
PTKU64_RS19095 (PTKU64_37680) 696108..697112 - 1005 WP_042316651.1 alpha-ketoacid dehydrogenase subunit beta -
PTKU64_RS19100 (PTKU64_37690) 697207..698184 - 978 WP_229514800.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-87)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13205.25 Da        Isoelectric Point: 9.3431

>T39850 WP_091776683.1 NZ_AP024956:c693733-693392 [Paraburkholderia terrae]
MAATFVELAPFRRCREDYLMDDEYRALQIVLMQNPEAGDVVRGTGGLRKLRFGDARRGKGKRGGLRVMYYYWVKGPQFWM
FTLYDKDEAEDLSSKERGVLSEMLREVIKLADR

Download         Length: 342 bp

>T39850 NZ_AP024956:c693733-693392 [Paraburkholderia terrae]
ATGGCGGCGACTTTCGTCGAACTGGCGCCTTTTCGACGGTGCCGGGAAGACTATTTGATGGACGACGAATATCGCGCACT
CCAGATTGTGCTGATGCAGAACCCGGAAGCGGGAGATGTCGTCAGGGGAACGGGCGGTCTGCGCAAACTCCGTTTCGGCG
ACGCACGTCGTGGGAAGGGAAAGCGCGGCGGGCTCAGGGTGATGTATTACTACTGGGTGAAAGGCCCGCAGTTCTGGATG
TTCACGCTATACGACAAGGACGAAGCGGAAGATTTATCGTCGAAGGAGCGAGGGGTTCTCTCCGAGATGCTGAGAGAAGT
CATCAAGCTTGCGGATCGATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11833.61 Da        Isoelectric Point: 9.7238

>AT39850 WP_086914644.1 NZ_AP024956:c693376-693065 [Paraburkholderia terrae]
MKRNLFAELTEGLDELKSAHEGKTTLHKVKVEIRDKLEVTADEIRAVRESINASQAVMARRLRVNERTYQNWEQGRAKPN
AQAAVLIKLVEKHPETIQMLETL

Download         Length: 312 bp

>AT39850 NZ_AP024956:c693376-693065 [Paraburkholderia terrae]
ATGAAACGGAATCTGTTTGCCGAATTGACGGAAGGGCTCGATGAACTCAAGTCCGCTCACGAAGGCAAGACAACACTTCA
CAAGGTCAAGGTTGAGATTCGTGACAAGCTGGAAGTGACGGCTGACGAGATCCGGGCCGTACGCGAATCCATCAACGCGT
CGCAGGCGGTCATGGCGCGTCGTCTGCGCGTGAACGAGCGGACCTATCAGAATTGGGAGCAAGGGCGGGCGAAGCCGAAC
GCCCAGGCTGCTGTGCTGATCAAGCTGGTTGAAAAGCATCCTGAGACGATACAGATGCTCGAAACCCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References