Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2080749..2082598 Replicon chromosome
Accession NZ_AP024885
Organism Vibrio neonatus strain JCM 21521

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OCU38_RS09630 Protein ID WP_261822921.1
Coordinates 2080749..2082098 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OCU38_RS09635 Protein ID WP_261822922.1
Coordinates 2082095..2082598 (+) Length 168 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU38_RS09600 2075930..2076415 + 486 WP_021712131.1 SsrA-binding protein SmpB -
OCU38_RS09610 2077098..2078231 + 1134 WP_261822917.1 XRE family transcriptional regulator -
OCU38_RS09615 2078228..2078728 + 501 WP_261822918.1 DUF4411 family protein -
OCU38_RS09620 2078828..2079073 - 246 WP_261822919.1 hypothetical protein -
OCU38_RS09625 2079159..2080256 - 1098 WP_261822920.1 hypothetical protein -
OCU38_RS09630 2080749..2082098 + 1350 WP_261822921.1 HipA domain-containing protein Toxin
OCU38_RS09635 2082095..2082598 + 504 WP_261822922.1 helix-turn-helix transcriptional regulator Antitoxin
OCU38_RS09640 2082886..2083170 - 285 WP_261824270.1 transposase -
OCU38_RS09645 2083299..2084630 + 1332 WP_261822923.1 AAA family ATPase -
OCU38_RS09650 2084782..2085684 - 903 WP_261822924.1 DMT family transporter -
OCU38_RS09655 2085775..2086710 + 936 WP_261822925.1 LysR family transcriptional regulator -
OCU38_RS09660 2086928..2087374 + 447 WP_261824271.1 DUF4823 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-148)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51180.87 Da        Isoelectric Point: 4.6750

>T39798 WP_261822921.1 NZ_AP024885:2080749-2082098 [Vibrio neonatus]
MESLTIQAYILEQWTDIACVTFPKSNEGNFITTEVHYLNEYAIENFEKDDNHAVSLNHPVNFFFDDKGRSGWLRFLDDII
PSGASRRYWVKQLDIGDLAIDQQDFILLKYGTISPVGNLRIKESLPKRTEKSDSLSFTLNDVIDRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRYSPKGQIWIDSYQDDVTNQDLYYLVKYPRGSRGKTDSNILRAEYCYYHELTSMGIDTIPIESMR
LEEGENYPSLWLPRFDIYVDDKQHMQRYAMESVYSILNKGPGSLLDHEDTIRQLIDKIINSHMVTEQGYQFNIQEFVIEW
VKRDLLNIIFGNSDNHGRNTSFIKKEGYIKLAPVYDFAPMKADPEGIPRATKWESPLEVGGEYDFDGIATSLSDLVPKET
LLKELKALAQNCLTLKERLEERGTPKQILDMPGIGMDFIAAKLGKWGLI

Download         Length: 1350 bp

>T39798 NZ_AP024885:2080749-2082098 [Vibrio neonatus]
ATGGAATCACTCACTATACAAGCTTACATACTAGAGCAATGGACTGATATAGCTTGTGTTACCTTCCCTAAAAGTAATGA
AGGCAACTTCATAACCACAGAAGTTCATTACCTAAACGAATATGCTATAGAAAACTTCGAGAAAGATGACAACCATGCCG
TTTCACTTAATCACCCTGTTAATTTCTTCTTTGACGATAAAGGGCGCTCAGGGTGGCTGAGGTTTCTCGATGACATAATA
CCGAGTGGAGCGAGTAGACGTTACTGGGTCAAGCAACTGGATATTGGAGATCTAGCTATTGACCAGCAAGATTTCATCCT
TTTGAAGTATGGAACTATCTCTCCAGTTGGTAATTTGAGAATAAAGGAATCACTACCAAAGCGGACTGAAAAATCAGATT
CACTGTCCTTTACCCTTAATGATGTAATCGATAGAGCTAGTGATTTTTTAGATTACGCACAAGAAAGGGGAGCTGCAGCT
GGAGGGGCTACTGGTGCAGGAGGTGAAGCTCCAAAACTACTACTGCGTTACTCCCCAAAAGGGCAAATCTGGATTGACAG
TTATCAAGATGACGTTACTAATCAAGATTTATATTATCTAGTAAAGTATCCGCGAGGATCTAGAGGGAAAACTGACAGCA
ATATTTTACGAGCTGAATATTGTTACTATCATGAGTTAACAAGCATGGGAATCGATACTATTCCAATAGAATCGATGCGA
TTAGAAGAAGGCGAAAATTACCCTTCTCTCTGGTTACCAAGATTTGATATCTATGTAGATGATAAGCAACACATGCAGCG
CTATGCCATGGAGTCGGTTTACTCAATTTTAAATAAAGGACCAGGTAGCCTTCTTGACCATGAGGATACTATTAGACAAC
TGATTGATAAAATTATAAATAGTCATATGGTTACTGAACAAGGCTATCAATTTAACATCCAAGAATTTGTTATTGAATGG
GTAAAAAGGGACTTACTCAATATCATATTTGGCAATAGCGATAACCATGGTAGAAATACTTCTTTCATCAAAAAAGAAGG
TTATATAAAACTTGCTCCAGTCTATGATTTTGCTCCAATGAAAGCAGACCCAGAAGGAATACCTAGAGCTACCAAGTGGG
AATCACCTTTAGAGGTAGGAGGTGAGTATGATTTTGACGGTATCGCGACTTCACTGTCAGATTTAGTTCCTAAAGAGACT
CTATTAAAAGAACTTAAAGCGCTTGCACAAAACTGTCTTACTTTAAAAGAAAGGTTAGAAGAAAGAGGAACACCAAAGCA
GATTTTGGATATGCCTGGTATAGGTATGGATTTCATTGCGGCAAAACTTGGTAAATGGGGGCTGATATGA

Antitoxin


Download         Length: 168 a.a.        Molecular weight: 18616.50 Da        Isoelectric Point: 10.6335

>AT39798 WP_261822922.1 NZ_AP024885:2082095-2082598 [Vibrio neonatus]
MSSNTDSLNRLDRLSLNTSAESVHDAISRLRLNKEHLSTAITIPKEHAQTSIGQIEKVAKRTPKNVQPISVSERKYKINR
VIRSLLMNELTQGLALKELRINVLGVKQDTFAKMVGVSRKTISEIENDRGTFKTDILDKVFKPFGLKVGLVPVSTNLLNL
ALSSHDD

Download         Length: 504 bp

>AT39798 NZ_AP024885:2082095-2082598 [Vibrio neonatus]
ATGAGTTCTAACACTGACAGTTTAAACCGATTAGATCGGCTTTCTCTAAACACTTCGGCAGAATCTGTGCATGATGCAAT
CTCCCGACTTCGTTTGAATAAAGAACACTTAAGTACGGCAATTACAATACCAAAAGAGCATGCTCAAACCTCGATTGGTC
AGATTGAAAAAGTGGCAAAGCGTACGCCTAAAAACGTACAACCAATATCAGTATCAGAAAGAAAATATAAGATAAATAGA
GTTATTAGATCGTTGCTTATGAACGAACTAACACAAGGATTAGCTCTCAAGGAGCTTAGGATAAACGTGTTAGGTGTCAA
ACAAGATACTTTTGCCAAAATGGTTGGGGTTTCCAGAAAAACTATATCTGAGATTGAGAATGATCGAGGTACTTTCAAAA
CTGATATTCTCGATAAAGTATTCAAGCCGTTTGGACTAAAAGTAGGGCTAGTACCTGTATCGACTAACCTACTAAATTTA
GCACTTAGCAGCCATGACGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References