Detailed information of TA system TA039777

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 59795..60330
• Replicon: plasmid pLMG19650
• Accession: NZ_AP024863
• Organism: Vibrio aerogenes strain LMG 19650

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCV29_RS23475
• Protein ID: WP_261887520.1
• Coordinates: 60055..60330 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: OCV29_RS23470
• Protein ID: WP_261887456.1
• Coordinates: 59795..60052 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV29_RS23460	55157..57316	-	2160	WP_261887454.1	type VI secretion system tip protein TssI/VgrG	-
OCV29_RS23465	58413..59675	+	1263	WP_261887455.1	replication initiation protein	-
OCV29_RS23470	59795..60052	+	258	WP_261887456.1	ribbon-helix-helix domain-containing protein	Antitoxin
OCV29_RS23475	60055..60330	+	276	WP_261887520.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV29_RS23480	60443..60646	-	204	WP_261887457.1	hypothetical protein	-
OCV29_RS23485	60984..61817	-	834	WP_261887458.1	hypothetical protein	-
OCV29_RS23490	62285..62935	+	651	WP_261887459.1	recombinase family protein	-
OCV29_RS23495	63409..64371	-	963	WP_261887460.1	type III-B CRISPR module RAMP protein Cmr6	-
OCV29_RS23500	64364..64843	-	480	WP_261887461.1	type III-B CRISPR module-associated protein Cmr5	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..85780	85780

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10914.55 Da
• Isoelectric Point: 9.3183

>T39777 WP_261887520.1 NZ_AP024863:60055-60330 [Vibrio aerogenes]
MDIKWSSKAYSDLKRLYEFLFPSDPRAAAKVVQSLTSAPDILYDQPRIGERLDAFEPREVRRLLVGHYEMRYEVQEAVVY
ILRIWHTREKR

Nucleotide

• Length: 276 bp

>T39777 NZ_AP024863:60055-60330 [Vibrio aerogenes]
ATGGATATCAAATGGAGTAGTAAAGCTTATTCTGATTTGAAGCGCTTATATGAATTTCTTTTTCCATCAGATCCCAGAGC
AGCTGCGAAAGTTGTGCAATCTTTAACTTCAGCTCCCGATATTTTATATGACCAACCCAGAATCGGTGAACGACTTGATG
CTTTTGAGCCGAGAGAAGTCAGGCGATTGTTAGTTGGCCATTATGAGATGAGATATGAAGTTCAGGAAGCTGTTGTTTAT
ATTTTACGTATTTGGCATACCCGGGAAAAACGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9701.94 Da
• Isoelectric Point: 5.1407

>AT39777 WP_261887456.1 NZ_AP024863:59795-60052 [Vibrio aerogenes]
MNTRVVTAHVPMHLADKVDELAQRLERSKAWIVKQALADWVVMEEERHKLTLEALADVDRGEVIDHQSVKDWAEGLDRGF
SGHES

Nucleotide

• Length: 258 bp

>AT39777 NZ_AP024863:59795-60052 [Vibrio aerogenes]
ATGAATACCCGAGTTGTCACTGCACATGTTCCGATGCACTTGGCTGATAAAGTTGATGAGTTGGCGCAACGTCTTGAACG
TTCTAAAGCCTGGATTGTTAAACAAGCACTGGCTGACTGGGTCGTTATGGAAGAAGAGCGGCATAAATTAACTCTGGAAG
CATTAGCTGATGTTGACCGTGGTGAAGTCATTGATCATCAGTCTGTTAAAGATTGGGCTGAAGGTCTTGATCGTGGATTT
TCAGGACATGAATCTTAA