Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2430465..2431126 Replicon chromosome
Accession NZ_AP024861
Organism Vibrio aerogenes strain LMG 19650

Toxin (Protein)


Gene name hicA Uniprot ID A0A1M6C2C0
Locus tag OCV29_RS10775 Protein ID WP_073605530.1
Coordinates 2430938..2431126 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1M6C254
Locus tag OCV29_RS10770 Protein ID WP_073605529.1
Coordinates 2430465..2430902 (-) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV29_RS10745 2427345..2427785 - 441 WP_073605525.1 hypothetical protein -
OCV29_RS10750 2427785..2428720 - 936 WP_073605526.1 phage tail tube protein -
OCV29_RS10755 2429174..2429551 - 378 WP_073605527.1 antiterminator Q family protein -
OCV29_RS10760 2429722..2429892 + 171 Protein_2103 helix-turn-helix domain-containing protein -
OCV29_RS10765 2429932..2430426 + 495 Protein_2104 helix-turn-helix transcriptional regulator -
OCV29_RS10770 2430465..2430902 - 438 WP_073605529.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OCV29_RS10775 2430938..2431126 - 189 WP_073605530.1 type II toxin-antitoxin system HicA family toxin Toxin
OCV29_RS10780 2431404..2431739 + 336 WP_073605531.1 hypothetical protein -
OCV29_RS10785 2432009..2432503 - 495 WP_073605532.1 hypothetical protein -
OCV29_RS10790 2432790..2434345 + 1556 WP_139281728.1 IS3 family transposase -
OCV29_RS10795 2435113..2436072 + 960 WP_073604097.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2408477..2434345 25868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7225.58 Da        Isoelectric Point: 10.6682

>T39773 WP_073605530.1 NZ_AP024861:c2431126-2430938 [Vibrio aerogenes]
MSSTELIKLLHKNGWELIGIRGSHHKFRHPEFQYPVIVPHPKKDLKIGLVKKLMQQAGLYTH

Download         Length: 189 bp

>T39773 NZ_AP024861:c2431126-2430938 [Vibrio aerogenes]
ATGAGTAGTACTGAGTTGATAAAACTTTTGCATAAAAACGGGTGGGAACTGATCGGTATCAGAGGCAGCCACCATAAATT
CCGGCATCCTGAGTTTCAGTATCCGGTGATTGTTCCGCATCCAAAGAAAGATTTAAAGATTGGACTGGTGAAAAAATTAA
TGCAGCAGGCAGGGTTATATACCCATTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16263.32 Da        Isoelectric Point: 4.4982

>AT39773 WP_073605529.1 NZ_AP024861:c2430902-2430465 [Vibrio aerogenes]
MLYPVAIETGDAEYAYSVVFPDLPGCFSAGDTLEEALANAREAVEFYLEDLAEHEQVPPSAGSLSDWQKDEAYQGWAWAV
IDIDLEPYLGGAVKKNVTLPKLLLKKIDNLVKQHPAYKDRSHFLQTAAFREIAQVKQQHPKTKDE

Download         Length: 438 bp

>AT39773 NZ_AP024861:c2430902-2430465 [Vibrio aerogenes]
ATGTTATATCCAGTTGCGATTGAAACCGGAGATGCAGAATACGCTTACAGCGTGGTATTTCCTGATTTACCGGGGTGTTT
CTCGGCGGGGGATACATTAGAAGAAGCGTTAGCCAATGCCAGAGAAGCCGTTGAATTTTATCTTGAAGATTTAGCCGAGC
ATGAACAGGTGCCACCATCGGCCGGGTCTTTGTCTGACTGGCAGAAAGATGAAGCTTATCAGGGCTGGGCGTGGGCTGTG
ATTGACATTGATCTTGAGCCTTATCTGGGGGGAGCAGTGAAAAAGAACGTCACGTTACCCAAATTGCTGCTAAAGAAAAT
TGATAATCTGGTCAAACAGCATCCGGCTTATAAAGATCGCTCGCACTTTTTGCAGACGGCGGCATTTCGTGAAATTGCGC
AGGTGAAGCAGCAACATCCAAAGACAAAAGATGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M6C2C0

Antitoxin

Source ID Structure
AlphaFold DB A0A1M6C254

References