Detailed information of TA system TA039343

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1608294..1608873
• Replicon: chromosome
• Accession: NZ_AP024734
• Organism: Staphylococcus aureus strain 59691

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: OCX19_RS07820
• Protein ID: WP_001025401.1
• Coordinates: 1608628..1608873 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1608294..1608659 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCX19_RS07780 (1605037)	1605037..1605594	-	558	WP_000645045.1	DUF2815 family protein	-
OCX19_RS07785 (1605620)	1605620..1606786	-	1167	WP_064129389.1	DUF2800 domain-containing protein	-
OCX19_RS07790 (1606783)	1606783..1607145	-	363	WP_000985976.1	hypothetical protein	-
OCX19_RS07795 (1607160)	1607160..1607483	-	324	WP_000174994.1	hypothetical protein	-
OCX19_RS07800 (1607562)	1607562..1607723	-	162	WP_001285963.1	DUF1270 family protein	-
OCX19_RS07805 (1607736)	1607736..1607999	-	264	WP_001124159.1	helix-turn-helix domain-containing protein	-
OCX19_RS07810 (1608024)	1608024..1608239	-	216	WP_001097552.1	hypothetical protein	-
OCX19_RS07815 (1608294)	1608294..1608659	+	366	WP_001128433.1	hypothetical protein	Antitoxin
OCX19_RS07820 (1608628)	1608628..1608873	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
OCX19_RS07825 (1608929)	1608929..1609138	+	210	WP_000642492.1	hypothetical protein	-
OCX19_RS07830 (1609128)	1609128..1609271	-	144	WP_000939498.1	hypothetical protein	-
OCX19_RS07835 (1609300)	1609300..1610076	-	777	WP_001148544.1	Rha family transcriptional regulator	-
OCX19_RS07840 (1610090)	1610090..1610326	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
OCX19_RS07845 (1610478)	1610478..1610792	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
OCX19_RS07850 (1610805)	1610805..1611266	+	462	WP_000525004.1	hypothetical protein	-
OCX19_RS07855 (1611284)	1611284..1611868	+	585	WP_000825948.1	hypothetical protein	-
OCX19_RS07860 (1612098)	1612098..1612244	+	147	WP_072433242.1	hypothetical protein	-
OCX19_RS07865 (1612241)	1612241..1612855	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1565718..1631813	66095

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T39343 WP_001025401.1 NZ_AP024734:c1608873-1608628 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T39343 NZ_AP024734:c1608873-1608628 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAACGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT39343 NZ_AP024734:1608294-1608659 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin