Detailed information of TA system TA038955

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 4737067..4737709
• Replicon: chromosome
• Accession: NZ_AP024617
• Organism: Shewanella algae strain TUM17386

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: -
• Locus tag: K5631_RS21100
• Protein ID: WP_208171344.1
• Coordinates: 4737287..4737709 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: A0A7X5Z2N1
• Locus tag: K5631_RS21095
• Protein ID: WP_028779782.1
• Coordinates: 4737067..4737306 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5631_RS21070 (TUM17386_41610)	4732750..4733577	+	828	WP_208171345.1	prolipoprotein diacylglyceryl transferase	-
K5631_RS21075 (TUM17386_41620)	4733577..4734371	+	795	WP_025887839.1	thymidylate synthase	-
K5631_RS21080 (TUM17386_41630)	4734488..4735663	+	1176	WP_025010547.1	Na+/H+ antiporter NhaA	-
K5631_RS21085 (TUM17386_41640)	4735660..4736043	+	384	WP_062793820.1	hypothetical protein	-
K5631_RS21090 (TUM17386_41650)	4736060..4736968	+	909	WP_025010548.1	transcriptional activator NhaR	-
K5631_RS21095 (TUM17386_41660)	4737067..4737306	+	240	WP_028779782.1	succinate dehydrogenase assembly factor 2	Antitoxin
K5631_RS21100	4737287..4737709	+	423	WP_208171344.1	protein YgfX	Toxin
K5631_RS21105 (TUM17386_41680)	4737727..4739337	-	1611	WP_025010550.1	L-aspartate oxidase	-
K5631_RS21110 (TUM17386_41690)	4739537..4740115	+	579	WP_025010551.1	RNA polymerase sigma factor RpoE	-
K5631_RS21115 (TUM17386_41700)	4740140..4740760	+	621	WP_025887842.1	RseA family anti-sigma factor	-
K5631_RS21120 (TUM17386_41710)	4740770..4741702	+	933	WP_025887844.1	MucB/RseB C-terminal domain-containing protein	-
K5631_RS21125 (TUM17386_41720)	4741713..4742192	+	480	WP_025887846.1	SoxR reducing system RseC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-135)

Antitoxin

• Flavinator of succinate dehydrogenase (5-75)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16335.94 Da
• Isoelectric Point: 7.0359

>T38955 WP_208171344.1 NZ_AP024617:4737287-4737709 [Shewanella algae]
VAGQRHRFQLSSSFSQYLSLTVLAAICLSSFLAWPALDYPFYLLFKYLCLLLMLAGFGLALWRLRCWQLCFWLNELGEGQ
FEPGLSFELSGRPWVSPFVVTFTYQGEDNYGRCWLFADMFDDTDYRHLCRLLLQRSKSAN

Nucleotide

• Length: 423 bp

>T38955 NZ_AP024617:4737287-4737709 [Shewanella algae]
GTGGCCGGGCAGCGCCATAGGTTTCAACTCAGTTCTTCCTTCAGCCAGTATCTGAGTCTGACGGTGCTGGCTGCTATTTG
CCTGAGCAGCTTTCTTGCCTGGCCAGCGCTGGATTATCCTTTCTATTTATTGTTCAAATACCTATGTTTACTGCTAATGC
TGGCAGGCTTTGGCCTTGCGCTGTGGCGTTTGCGCTGCTGGCAACTCTGTTTCTGGCTTAATGAATTGGGTGAAGGACAG
TTCGAACCCGGTTTGAGTTTCGAACTTAGTGGCAGACCTTGGGTCAGCCCCTTTGTGGTGACTTTTACCTATCAGGGGGA
GGATAACTACGGGCGTTGCTGGCTGTTTGCCGATATGTTTGACGACACAGACTATCGTCACCTGTGTCGTCTATTGTTGC
AGCGCTCAAAGTCCGCTAACTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9247.74 Da
• Isoelectric Point: 5.0633

>AT38955 WP_028779782.1 NZ_AP024617:4737067-4737306 [Shewanella algae]
MSTPRVKWACRRGMLELDVLFQPFVEQHYETLSPEDKALFVRLLECEDPELFAWFMGHEQCPDPQLAQMVVRVRGRAAP

Nucleotide

• Length: 240 bp

>AT38955 NZ_AP024617:4737067-4737306 [Shewanella algae]
ATGAGTACCCCCAGGGTTAAGTGGGCATGTCGCCGTGGTATGCTGGAGCTTGATGTACTGTTTCAACCCTTTGTGGAACA
GCATTACGAGACTCTGAGCCCTGAGGATAAGGCCTTGTTTGTTCGTCTGCTTGAGTGTGAAGATCCTGAGCTCTTTGCCT
GGTTTATGGGGCATGAGCAATGTCCGGATCCGCAACTGGCACAGATGGTAGTGCGCGTTCGTGGCCGGGCAGCGCCATAG

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z2N1