Detailed information of TA system TA038945

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 3602581..3603223
• Replicon: chromosome
• Accession: NZ_AP024614
• Organism: Shewanella algae strain TUM17382

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: A0A5N5U1D5
• Locus tag: K5638_RS16125
• Protein ID: WP_025010549.1
• Coordinates: 3602581..3603003 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: A0A7X5Z2N1
• Locus tag: K5638_RS16130
• Protein ID: WP_028779782.1
• Coordinates: 3602984..3603223 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5638_RS16100 (TUM17382_31690)	3598098..3598577	-	480	WP_221060072.1	SoxR reducing system RseC family protein	-
K5638_RS16105 (TUM17382_31700)	3598588..3599520	-	933	WP_221060073.1	MucB/RseB C-terminal domain-containing protein	-
K5638_RS16110 (TUM17382_31710)	3599530..3600150	-	621	WP_221060074.1	RseA family anti-sigma factor	-
K5638_RS16115 (TUM17382_31720)	3600175..3600753	-	579	WP_025010551.1	RNA polymerase sigma factor RpoE	-
K5638_RS16120 (TUM17382_31730)	3600953..3602563	+	1611	WP_025010550.1	L-aspartate oxidase	-
K5638_RS16125 (TUM17382_31740)	3602581..3603003	-	423	WP_025010549.1	protein YgfX	Toxin
K5638_RS16130 (TUM17382_31750)	3602984..3603223	-	240	WP_028779782.1	succinate dehydrogenase assembly factor 2	Antitoxin
K5638_RS16135 (TUM17382_31760)	3603322..3604230	-	909	WP_025010548.1	transcriptional activator NhaR	-
K5638_RS16140 (TUM17382_31770)	3604247..3604630	-	384	WP_062793820.1	hypothetical protein	-
K5638_RS16145 (TUM17382_31780)	3604627..3605802	-	1176	WP_025010547.1	Na+/H+ antiporter NhaA	-
K5638_RS16150 (TUM17382_31790)	3605919..3606713	-	795	WP_144438590.1	thymidylate synthase	-
K5638_RS16155 (TUM17382_31800)	3606713..3607540	-	828	WP_208242885.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-135)

Antitoxin

• Flavinator of succinate dehydrogenase (5-75)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16309.86 Da
• Isoelectric Point: 7.0359

>T38945 WP_025010549.1 NZ_AP024614:c3603003-3602581 [Shewanella algae]
VAGQRHRFQLSSSFSQYLSLTVLAAICLSSFLAWPALDYPFYLLFKYLCLLLMLAGFGLALWRLRCWQLCFWLNELGEGQ
FEPGSSFELSGRPWVSPFVVTFTYQGEDNYGRCWLFADMFDDTDYRHLCRLLLQRSKSAN

Nucleotide

• Length: 423 bp

>T38945 NZ_AP024614:c3603003-3602581 [Shewanella algae]
GTGGCCGGGCAGCGCCATAGGTTTCAACTCAGTTCTTCCTTCAGCCAGTATCTGAGTCTGACGGTGCTGGCTGCTATTTG
CCTGAGCAGCTTTCTTGCCTGGCCGGCGCTGGATTATCCTTTCTATTTATTGTTCAAATACCTATGTTTACTGCTAATGC
TGGCAGGCTTTGGCCTTGCGCTGTGGCGTTTGCGCTGCTGGCAACTCTGTTTCTGGCTTAATGAATTGGGTGAAGGACAG
TTCGAACCCGGTTCGAGTTTCGAACTTAGTGGCAGACCTTGGGTCAGCCCCTTTGTGGTGACTTTTACCTATCAGGGGGA
GGATAACTACGGGCGTTGCTGGCTGTTTGCCGATATGTTTGACGACACAGACTATCGTCACCTGTGTCGTCTATTGTTGC
AGCGCTCAAAGTCCGCTAACTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9247.74 Da
• Isoelectric Point: 5.0633

>AT38945 WP_028779782.1 NZ_AP024614:c3603223-3602984 [Shewanella algae]
MSTPRVKWACRRGMLELDVLFQPFVEQHYETLSPEDKALFVRLLECEDPELFAWFMGHEQCPDPQLAQMVVRVRGRAAP

Nucleotide

• Length: 240 bp

>AT38945 NZ_AP024614:c3603223-3602984 [Shewanella algae]
ATGAGTACCCCCAGGGTTAAGTGGGCATGTCGCCGTGGTATGCTGGAGCTTGATGTACTGTTTCAACCCTTTGTGGAACA
GCATTACGAGACTCTGAGCCCTGAGGATAAGGCCTTGTTTGTTCGTCTGCTTGAGTGTGAAGATCCTGAGCTCTTTGCCT
GGTTTATGGGGCATGAGCAATGTCCGGATCCGCAACTGGCACAGATGGTAGTGCGCGTTCGTGGCCGGGCAGCGCCATAG

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z2N1