Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4929243..4929770 Replicon chromosome
Accession NZ_AP024592
Organism Klebsiella variicola strain JCM 12419

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KI238_RS23865 Protein ID WP_119867156.1
Coordinates 4929243..4929518 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KI238_RS23870 Protein ID WP_119867157.1
Coordinates 4929522..4929770 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI238_RS23850 (KLVA_46350) 4925250..4926929 + 1680 WP_119867154.1 glycoside hydrolase family 43 protein -
KI238_RS23855 (KLVA_46360) 4927174..4928043 + 870 WP_087653704.1 HNH endonuclease -
KI238_RS23860 (KLVA_46370) 4928324..4929121 - 798 WP_119867155.1 helix-turn-helix domain-containing protein -
KI238_RS23865 (KLVA_46380) 4929243..4929518 - 276 WP_119867156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI238_RS23870 (KLVA_46390) 4929522..4929770 - 249 WP_119867157.1 ribbon-helix-helix domain-containing protein Antitoxin
KI238_RS23875 (KLVA_46400) 4929847..4930680 - 834 WP_119867158.1 DUF4942 domain-containing protein -
KI238_RS23880 (KLVA_46410) 4930795..4931136 - 342 WP_119867159.1 TA system toxin CbtA family protein -
KI238_RS23885 (KLVA_46420) 4931172..4931498 - 327 WP_119867160.1 type IV toxin-antitoxin system YeeU family antitoxin -
KI238_RS23890 (KLVA_46430) 4931543..4932016 - 474 WP_119867161.1 DNA repair protein RadC -
KI238_RS23895 (KLVA_46440) 4932087..4932908 - 822 WP_119867162.1 DUF932 domain-containing protein -
KI238_RS23900 (KLVA_46450) 4933005..4933472 - 468 Protein_4704 hypothetical protein -
KI238_RS23905 (KLVA_46460) 4933517..4934017 - 501 WP_227518038.1 hypothetical protein -
KI238_RS23910 (KLVA_46470) 4934041..4934730 - 690 WP_119867163.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-44)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11071.37 Da        Isoelectric Point: 4.5714

>T38896 WP_119867156.1 NZ_AP024592:c4929518-4929243 [Klebsiella variicola]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLITGCADLATHPAIGAQQPWYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Download         Length: 276 bp

>T38896 NZ_AP024592:c4929518-4929243 [Klebsiella variicola]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGACCTGGAACGTATCTACCGTTTCGCTCTTCAGTATAGCCGCCAGCA
CGCCGATGACGTTTTGGATCGCCTGATTACTGGCTGCGCTGACCTTGCAACGCATCCGGCAATTGGCGCACAGCAGCCTT
GGTATGAACCTCGGGAAGTCCGGAAAGTGTTATTTGATGATTACGAGGTTCACTACGAACTTCGTGACAATGACATCTAT
ATCGTGGATCTCTGGCATACCAAAGAAGAACGTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9014.35 Da        Isoelectric Point: 8.8294

>AT38896 WP_119867157.1 NZ_AP024592:c4929770-4929522 [Klebsiella variicola]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTNMLAERERRHQSIQAGLADVDAGRVVSHSNMVDFANRLK
KA

Download         Length: 249 bp

>AT38896 NZ_AP024592:c4929770-4929522 [Klebsiella variicola]
ATGGGTTCGCTTACTAAACAAACCATCAGCGCACAGATACCCGTTGAATTGGCTGCTGCTGTTGAGAATCTGGCAATTGA
GTTGGACCGTTCTAAGAGCTGGATTATTAAAGAAGCATTGACCAATATGCTGGCCGAACGAGAACGGCGTCATCAGAGTA
TCCAAGCAGGTCTTGCTGATGTGGATGCCGGTCGTGTGGTGAGTCATTCGAACATGGTGGATTTCGCTAACCGTTTAAAG
AAAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References