Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 78457..79260 | Replicon | chromosome |
| Accession | NZ_AP024585 | ||
| Organism | Citrobacter amalonaticus strain JCM 1661 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7L6YXS7 |
| Locus tag | KI228_RS00390 | Protein ID | WP_046401692.1 |
| Coordinates | 78457..78837 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | KI228_RS00395 | Protein ID | WP_046401691.1 |
| Coordinates | 78895..79260 (-) | Length | 122 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KI228_RS00370 (CIAM_00720) | 74169..75014 | + | 846 | WP_042323385.1 | fructoselysine 6-kinase | - |
| KI228_RS00375 (CIAM_00730) | 75076..76395 | + | 1320 | WP_042323383.1 | anaerobic C4-dicarboxylate transporter | - |
| KI228_RS00380 (CIAM_00740) | 76809..77660 | - | 852 | WP_090050165.1 | DUF4942 domain-containing protein | - |
| KI228_RS24255 | 77743..77939 | - | 197 | Protein_76 | hypothetical protein | - |
| KI228_RS00385 (CIAM_00750) | 77969..78460 | - | 492 | WP_046401693.1 | DUF5983 family protein | - |
| KI228_RS00390 (CIAM_00760) | 78457..78837 | - | 381 | WP_046401692.1 | TA system toxin CbtA family protein | Toxin |
| KI228_RS00395 (CIAM_00770) | 78895..79260 | - | 366 | WP_046401691.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| KI228_RS00400 (CIAM_00780) | 79283..79504 | - | 222 | WP_038633763.1 | DUF987 domain-containing protein | - |
| KI228_RS00405 (CIAM_00790) | 79516..80001 | - | 486 | WP_038642868.1 | DNA repair protein RadC | - |
| KI228_RS00410 (CIAM_00800) | 80054..80449 | - | 396 | WP_046401710.1 | antirestriction protein | - |
| KI228_RS00415 (CIAM_00810) | 80527..80790 | - | 264 | WP_001149870.1 | hypothetical protein | - |
| KI228_RS00420 (CIAM_00820) | 80790..81608 | - | 819 | WP_001234374.1 | DUF932 domain-containing protein | - |
| KI228_RS00425 | 81724..81974 | - | 251 | Protein_85 | DUF905 family protein | - |
| KI228_RS00430 (CIAM_00840) | 82165..82632 | - | 468 | WP_000727137.1 | hypothetical protein | - |
| KI228_RS00435 (CIAM_00850) | 82729..83130 | - | 402 | WP_000819262.1 | hypothetical protein | - |
| KI228_RS00440 (CIAM_00860) | 83336..84223 | - | 888 | WP_040229917.1 | 50S ribosome-binding GTPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 14234.49 Da Isoelectric Point: 10.6224
>T38861 WP_046401692.1 NZ_AP024585:c78837-78457 [Citrobacter amalonaticus]
MQTLSAIPTRKAPSRPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEKIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQKQHS
MQTLSAIPTRKAPSRPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEKIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQKQHS
Download Length: 381 bp
>T38861 NZ_AP024585:c78837-78457 [Citrobacter amalonaticus]
ATGCAAACCTTATCCGCCATCCCGACGCGGAAGGCACCGTCACGCCCGACGCCCGTTGAAATCTGGCAGCAACTTCTTAC
GTATCTGTTAAAAAGACATTACGGCCTTTCGCTTAGCGACACGCAATTTTCCGATGAGAAGATTATTACGCAATATATTG
ACGCCGGTATCTCACTGTCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTGCGGATTGATCGTCCCGGTTTC
TCCATTAAGCATCAGTCCCCTTTTATCGGGGTGATTGATATTCTCCGGGCCAGACGGGCAACGGGTTTGATGCAACGTAA
CGGGTATAAAAGGATCACTCTTCTCATCGCTGGAAATGCAGCTCAGAAGCAACATTCATGA
ATGCAAACCTTATCCGCCATCCCGACGCGGAAGGCACCGTCACGCCCGACGCCCGTTGAAATCTGGCAGCAACTTCTTAC
GTATCTGTTAAAAAGACATTACGGCCTTTCGCTTAGCGACACGCAATTTTCCGATGAGAAGATTATTACGCAATATATTG
ACGCCGGTATCTCACTGTCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTGCGGATTGATCGTCCCGGTTTC
TCCATTAAGCATCAGTCCCCTTTTATCGGGGTGATTGATATTCTCCGGGCCAGACGGGCAACGGGTTTGATGCAACGTAA
CGGGTATAAAAGGATCACTCTTCTCATCGCTGGAAATGCAGCTCAGAAGCAACATTCATGA
Antitoxin
Download Length: 122 a.a. Molecular weight: 13600.49 Da Isoelectric Point: 7.1029
>AT38861 WP_046401691.1 NZ_AP024585:c79260-78895 [Citrobacter amalonaticus]
MLNKTLPANHHISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQAFPALLKQLELMLVSGELN
PRHQHCVTLYAKGLTCEADSLGSHGYIYTAIYPTPDDSITR
MLNKTLPANHHISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQAFPALLKQLELMLVSGELN
PRHQHCVTLYAKGLTCEADSLGSHGYIYTAIYPTPDDSITR
Download Length: 366 bp
>AT38861 NZ_AP024585:c79260-78895 [Citrobacter amalonaticus]
TTGTTGAATAAAACACTGCCGGCAAATCATCATATTTCTGAACCGTGGTGGGGACTGAAACGTAATATCACCCCGTGCTT
CGGTGCACGGCTGGTACAGGAAGGCAACCGGCTGCATTATCTGGCCGACCGCGCCAGCATCACCGGGACATTCACCGACG
CGGATTTGCGCCATCTCGACCAAGCGTTTCCGGCACTGCTCAAACAGCTGGAATTAATGCTGGTTTCCGGTGAGCTCAAT
CCCCGCCATCAGCACTGTGTCACGTTATATGCAAAAGGACTGACCTGTGAAGCAGATTCCCTCGGATCACATGGCTACAT
TTATACAGCAATTTATCCGACACCAGACGACAGCATAACCCGGTAA
TTGTTGAATAAAACACTGCCGGCAAATCATCATATTTCTGAACCGTGGTGGGGACTGAAACGTAATATCACCCCGTGCTT
CGGTGCACGGCTGGTACAGGAAGGCAACCGGCTGCATTATCTGGCCGACCGCGCCAGCATCACCGGGACATTCACCGACG
CGGATTTGCGCCATCTCGACCAAGCGTTTCCGGCACTGCTCAAACAGCTGGAATTAATGCTGGTTTCCGGTGAGCTCAAT
CCCCGCCATCAGCACTGTGTCACGTTATATGCAAAAGGACTGACCTGTGAAGCAGATTCCCTCGGATCACATGGCTACAT
TTATACAGCAATTTATCCGACACCAGACGACAGCATAACCCGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|