Detailed information of TA system TA038660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 736120..736658
• Replicon: chromosome
• Accession: NZ_AP024552
• Organism: Vibrio cholerae strain IDH-02387

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q9KMJ0
• Locus tag: K6J81_RS17610
• Protein ID: WP_000802136.1
• Coordinates: 736359..736658 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P58093
• Locus tag: K6J81_RS17605
• Protein ID: WP_001107719.1
• Coordinates: 736120..736362 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J81_RS17570	731536..731676	-	141	WP_001883049.1	DUF3265 domain-containing protein	-
K6J81_RS17575	731642..732577	-	936	WP_000051985.1	restriction endonuclease	-
K6J81_RS17580	732858..733457	-	600	WP_000429495.1	DUF6338 family protein	-
K6J81_RS17585	733612..733878	-	267	WP_000937852.1	hypothetical protein	-
K6J81_RS17590	734092..734775	-	684	WP_000877436.1	hypothetical protein	-
K6J81_RS17595	735199..735291	-	93	WP_014164112.1	DUF3265 domain-containing protein	-
K6J81_RS17600	735313..735891	-	579	WP_000110120.1	hypothetical protein	-
K6J81_RS17605	736120..736362	+	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
K6J81_RS17610	736359..736658	+	300	WP_000802136.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K6J81_RS17615	736786..737181	-	396	WP_000870857.1	DUF3465 domain-containing protein	-
K6J81_RS17620	737395..737574	-	180	WP_001883058.1	DUF645 family protein	-
K6J81_RS17625	738152..738241	-	90	WP_072606010.1	DUF3265 domain-containing protein	-
K6J81_RS17630	738272..738970	-	699	WP_001890502.1	hypothetical protein	-
K6J81_RS17635	739093..739719	-	627	WP_000365424.1	LysE family translocator	-
K6J81_RS17640	739761..739853	-	93	WP_014378730.1	DUF3265 domain-containing protein	-
K6J81_RS17645	739868..740341	-	474	WP_001161076.1	GrpB family protein	-
K6J81_RS17650	740541..740723	-	183	WP_000923182.1	DUF645 family protein	-
K6J81_RS19340	740784..740921	-	138	WP_001890145.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	730402..773207	42805

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11589.29 Da
• Isoelectric Point: 9.9232

>T38660 WP_000802136.1 NZ_AP024552:736359-736658 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Nucleotide

• Length: 300 bp

>T38660 NZ_AP024552:736359-736658 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8964.84 Da
• Isoelectric Point: 4.1677

>AT38660 WP_001107719.1 NZ_AP024552:736120-736362 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Nucleotide

• Length: 243 bp

>AT38660 NZ_AP024552:736120-736362 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Structures

Toxin

• PDB: 7R5A

Antitoxin

• AlphaFold DB: A0A151JFU4