Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 817967..818526 Replicon chromosome
Accession NZ_AP024550
Organism Vibrio cholerae strain IDH-00113

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag K6J78_RS17230 Protein ID WP_000578476.1
Coordinates 817967..818245 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag K6J78_RS17235 Protein ID WP_000381183.1
Coordinates 818242..818526 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J78_RS17190 813045..813551 + 507 WP_000393074.1 hypothetical protein -
K6J78_RS17195 813708..814094 + 387 WP_000703163.1 VOC family protein -
K6J78_RS17200 814351..814554 + 204 WP_001911580.1 hypothetical protein -
K6J78_RS17205 814749..815000 + 252 WP_001890111.1 TIGR03643 family protein -
K6J78_RS18720 814973..815122 + 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J78_RS17210 815269..815694 + 426 WP_000415750.1 hypothetical protein -
K6J78_RS17215 815900..816523 + 624 WP_000247070.1 DUF1349 domain-containing protein -
K6J78_RS17220 816736..817215 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
K6J78_RS18725 817212..817328 + 117 WP_086010882.1 DUF3265 domain-containing protein -
K6J78_RS17225 817403..817816 + 414 WP_000049420.1 VOC family protein -
K6J78_RS17230 817967..818245 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K6J78_RS17235 818242..818526 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J78_RS17240 818775..819236 + 462 WP_001911578.1 lipocalin family protein -
K6J78_RS17245 819301..819897 + 597 WP_000255434.1 hypothetical protein -
K6J78_RS18730 820091..820228 + 138 WP_001890145.1 hypothetical protein -
K6J78_RS17250 820289..820471 + 183 WP_000923182.1 DUF645 family protein -
K6J78_RS17255 820671..821144 + 474 WP_001161076.1 GrpB family protein -
K6J78_RS17260 821159..821251 + 93 WP_014378730.1 DUF3265 domain-containing protein -
K6J78_RS17265 821293..821919 + 627 WP_000365424.1 LysE family translocator -
K6J78_RS17270 822042..822740 + 699 WP_001890502.1 hypothetical protein -
K6J78_RS17275 822771..822860 + 90 WP_072606010.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 782725..888585 105860
- inside Integron - - 787805..830610 42805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T38638 WP_000578476.1 NZ_AP024550:c818245-817967 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T38638 NZ_AP024550:c818245-817967 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT38638 WP_000381183.1 NZ_AP024550:c818526-818242 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT38638 NZ_AP024550:c818526-818242 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References