Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2452287..2452471 Replicon chromosome
Accession NZ_AP024511
Organism Staphylococcus aureus isolate 2007-13

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag KJS82_RS12060 Protein ID WP_000482652.1
Coordinates 2452287..2452394 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2452411..2452471 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJS82_RS12035 2447649..2448122 + 474 WP_000456486.1 GyrI-like domain-containing protein -
KJS82_RS12040 2448245..2449456 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
KJS82_RS12045 2449638..2450297 - 660 WP_000831298.1 membrane protein -
KJS82_RS12050 2450357..2451499 - 1143 WP_001176863.1 glycerate kinase -
KJS82_RS12055 2451767..2452153 + 387 WP_000779360.1 flippase GtxA -
KJS82_RS12060 2452287..2452394 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2452411..2452471 - 61 - - Antitoxin
KJS82_RS12065 2453097..2454860 + 1764 WP_001064825.1 ABC transporter ATP-binding protein -
KJS82_RS12070 2454885..2456618 + 1734 WP_000486487.1 ABC transporter ATP-binding protein -
KJS82_RS12075 2456885..2457016 + 132 WP_223197975.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T38530 WP_000482652.1 NZ_AP024511:2452287-2452394 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T38530 NZ_AP024511:2452287-2452394 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT38530 NZ_AP024511:c2452471-2452411 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References