Detailed information of TA system TA038284

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1380140..1380623
• Replicon: chromosome
• Accession: NZ_AP024276
• Organism: Streptococcus parasuis strain SUT-286

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L6410_RS06910
• Protein ID: WP_172016284.1
• Coordinates: 1380140..1380400 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: L6410_RS06915
• Protein ID: WP_024404858.1
• Coordinates: 1380402..1380623 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6410_RS06885 (SUT286_13280)	1375524..1376753	-	1230	WP_024391930.1	tetratricopeptide repeat protein	-
L6410_RS06890 (SUT286_13290)	1376743..1377909	-	1167	WP_024397410.1	AI-2E family transporter	-
L6410_RS06895 (SUT286_13300)	1378044..1379045	+	1002	WP_237395186.1	lactonase family protein	-
L6410_RS06900 (SUT286_13310)	1379112..1379297	+	186	WP_237395187.1	hypothetical protein	-
L6410_RS06905 (SUT286_13320)	1379326..1379973	-	648	WP_237395188.1	HAD family hydrolase	-
L6410_RS06910 (SUT286_13330)	1380140..1380400	-	261	WP_172016284.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L6410_RS06915 (SUT286_13340)	1380402..1380623	-	222	WP_024404858.1	DUF6290 family protein	Antitoxin
L6410_RS06920 (SUT286_13350)	1381143..1382450	-	1308	WP_024391935.1	phosphopyruvate hydratase	-
L6410_RS06925 (SUT286_13360)	1382600..1383064	+	465	WP_237395189.1	DUF1694 domain-containing protein	-
L6410_RS06930 (SUT286_13370)	1383097..1384848	-	1752	WP_237395190.1	IS1634 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10340.91 Da
• Isoelectric Point: 9.9167

>T38284 WP_172016284.1 NZ_AP024276:c1380400-1380140 [Streptococcus parasuis]
MYRLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTENPRANGKGLTGNHAHEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDIY

Nucleotide

• Length: 261 bp

>T38284 NZ_AP024276:c1380400-1380140 [Streptococcus parasuis]
ATGTATCGTTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGCTATTTGC
TTGGATTGATAAGCACTTAGAAGGGACTGAAAATCCACGCGCCAATGGTAAAGGTTTGACAGGTAATCATGCTCACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATATCTATTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8565.57 Da
• Isoelectric Point: 4.6104

>AT38284 WP_024404858.1 NZ_AP024276:c1380623-1380402 [Streptococcus parasuis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKANPETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT38284 NZ_AP024276:c1380623-1380402 [Streptococcus parasuis]
ATGAGTACAGTAACTATCAGATTAAATCAAGAAGAAGAGGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAAATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG