Detailed information of TA system TA038272

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 3020314..3021306
• Replicon: chromosome
• Accession: NZ_AP024266
• Organism: Mycobacterium intracellulare strain M.i.27

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: JN183_RS14270
• Protein ID: WP_201407898.1
• Coordinates: 3020728..3021306 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A7I7TS83
• Locus tag: JN183_RS14265
• Protein ID: WP_009956380.1
• Coordinates: 3020314..3020703 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN183_RS14240	3015767..3017770	+	2004	WP_201407740.1	phosphotransferase	-
JN183_RS14245	3017767..3018312	+	546	WP_051012195.1	gluconokinase	-
JN183_RS14250	3018336..3018947	-	612	WP_014384642.1	TetR/AcrR family transcriptional regulator	-
JN183_RS14255	3019138..3019941	+	804	WP_202287172.1	SAM-dependent methyltransferase	-
JN183_RS14260	3019981..3020256	+	276	WP_038536176.1	hypothetical protein	-
JN183_RS14265	3020314..3020703	+	390	WP_009956380.1	hypothetical protein	Antitoxin
JN183_RS14270	3020728..3021306	+	579	WP_201407898.1	zeta toxin family protein	Toxin
JN183_RS14275	3021326..3022393	-	1068	WP_014380064.1	DoxX family membrane protein	-
JN183_RS14280	3022489..3023049	+	561	WP_201407897.1	isochorismatase family protein	-
JN183_RS14285	3023049..3023849	+	801	WP_201407896.1	nuclear transport factor 2 family protein	-
JN183_RS14290	3023861..3024211	-	351	WP_009956374.1	DoxX family protein	-
JN183_RS14295	3024377..3025348	+	972	WP_202287070.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-138)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21047.20 Da
• Isoelectric Point: 11.1019

>T38272 WP_201407898.1 NZ_AP024266:3020728-3021306 [Mycobacterium intracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYDAAKIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T38272 NZ_AP024266:3020728-3021306 [Mycobacterium intracellulare]
ATGCAGCGACTTGACCTGGTAGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAGATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGAAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTCCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTCTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13512.89 Da
• Isoelectric Point: 5.1828

>AT38272 WP_009956380.1 NZ_AP024266:3020314-3020703 [Mycobacterium intracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT38272 NZ_AP024266:3020314-3020703 [Mycobacterium intracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I7TS83