Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2499266..2500258 Replicon chromosome
Accession NZ_AP024257
Organism Mycobacterium paraintracellulare strain M019

Toxin (Protein)


Gene name pezT Uniprot ID J9WIQ3
Locus tag JN215_RS11605 Protein ID WP_014941867.1
Coordinates 2499680..2500258 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A7I7TS83
Locus tag JN215_RS11600 Protein ID WP_009956380.1
Coordinates 2499266..2499655 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN215_RS11575 2494717..2496720 + 2004 WP_201358461.1 phosphotransferase -
JN215_RS11580 2496717..2497217 + 501 WP_014384641.1 gluconokinase -
JN215_RS11585 2497288..2497899 - 612 WP_009956383.1 TetR/AcrR family transcriptional regulator -
JN215_RS11590 2498069..2498893 + 825 WP_201408229.1 SAM-dependent methyltransferase -
JN215_RS11595 2498933..2499208 + 276 WP_038536176.1 hypothetical protein -
JN215_RS11600 2499266..2499655 + 390 WP_009956380.1 hypothetical protein Antitoxin
JN215_RS11605 2499680..2500258 + 579 WP_014941867.1 zeta toxin family protein Toxin
JN215_RS11610 2500278..2501345 - 1068 WP_014380064.1 DoxX family membrane protein -
JN215_RS11615 2501441..2502001 + 561 WP_158020468.1 pyrazinamidase PncA -
JN215_RS11620 2502001..2502801 + 801 WP_009956375.1 nuclear transport factor 2 family protein -
JN215_RS11625 2502813..2503163 - 351 WP_009956374.1 DoxX family protein -
JN215_RS11630 2503329..2504300 + 972 WP_014941870.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-138)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21005.20 Da        Isoelectric Point: 11.0232

>T38241 WP_014941867.1 NZ_AP024257:2499680-2500258 [Mycobacterium paraintracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGDAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTALRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMIIGSPDWPAWAPEILRSRWPD

Download         Length: 579 bp

>T38241 NZ_AP024257:2499680-2500258 [Mycobacterium paraintracellulare]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGATGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCTCCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGATTATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13512.89 Da        Isoelectric Point: 5.1828

>AT38241 WP_009956380.1 NZ_AP024257:2499266-2499655 [Mycobacterium paraintracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Download         Length: 390 bp

>AT38241 NZ_AP024257:2499266-2499655 [Mycobacterium paraintracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGACGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J9WIQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7TS83

References