Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 2499266..2500258 | Replicon | chromosome |
| Accession | NZ_AP024257 | ||
| Organism | Mycobacterium paraintracellulare strain M019 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | J9WIQ3 |
| Locus tag | JN215_RS11605 | Protein ID | WP_014941867.1 |
| Coordinates | 2499680..2500258 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | A0A7I7TS83 |
| Locus tag | JN215_RS11600 | Protein ID | WP_009956380.1 |
| Coordinates | 2499266..2499655 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN215_RS11575 | 2494717..2496720 | + | 2004 | WP_201358461.1 | phosphotransferase | - |
| JN215_RS11580 | 2496717..2497217 | + | 501 | WP_014384641.1 | gluconokinase | - |
| JN215_RS11585 | 2497288..2497899 | - | 612 | WP_009956383.1 | TetR/AcrR family transcriptional regulator | - |
| JN215_RS11590 | 2498069..2498893 | + | 825 | WP_201408229.1 | SAM-dependent methyltransferase | - |
| JN215_RS11595 | 2498933..2499208 | + | 276 | WP_038536176.1 | hypothetical protein | - |
| JN215_RS11600 | 2499266..2499655 | + | 390 | WP_009956380.1 | hypothetical protein | Antitoxin |
| JN215_RS11605 | 2499680..2500258 | + | 579 | WP_014941867.1 | zeta toxin family protein | Toxin |
| JN215_RS11610 | 2500278..2501345 | - | 1068 | WP_014380064.1 | DoxX family membrane protein | - |
| JN215_RS11615 | 2501441..2502001 | + | 561 | WP_158020468.1 | pyrazinamidase PncA | - |
| JN215_RS11620 | 2502001..2502801 | + | 801 | WP_009956375.1 | nuclear transport factor 2 family protein | - |
| JN215_RS11625 | 2502813..2503163 | - | 351 | WP_009956374.1 | DoxX family protein | - |
| JN215_RS11630 | 2503329..2504300 | + | 972 | WP_014941870.1 | sigma-70 family RNA polymerase sigma factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21005.20 Da Isoelectric Point: 11.0232
>T38241 WP_014941867.1 NZ_AP024257:2499680-2500258 [Mycobacterium paraintracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGDAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTALRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMIIGSPDWPAWAPEILRSRWPD
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGDAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTALRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMIIGSPDWPAWAPEILRSRWPD
Download Length: 579 bp
>T38241 NZ_AP024257:2499680-2500258 [Mycobacterium paraintracellulare]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGATGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCTCCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGATTATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGATGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCTCCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGATTATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG
Antitoxin
Download Length: 130 a.a. Molecular weight: 13512.89 Da Isoelectric Point: 5.1828
>AT38241 WP_009956380.1 NZ_AP024257:2499266-2499655 [Mycobacterium paraintracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
Download Length: 390 bp
>AT38241 NZ_AP024257:2499266-2499655 [Mycobacterium paraintracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGACGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGACGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | J9WIQ3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7I7TS83 |