Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2563990..2564982 Replicon chromosome
Accession NZ_AP024253
Organism Mycobacterium paraintracellulare strain M015

Toxin (Protein)


Gene name pezT Uniprot ID J9WIQ3
Locus tag JN176_RS11880 Protein ID WP_014941867.1
Coordinates 2564404..2564982 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A7I7TS83
Locus tag JN176_RS11875 Protein ID WP_009956380.1
Coordinates 2563990..2564379 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN176_RS11850 2559441..2561444 + 2004 WP_014384640.1 phosphotransferase -
JN176_RS11855 2561441..2561941 + 501 WP_014384641.1 gluconokinase -
JN176_RS11860 2562012..2562623 - 612 WP_009956383.1 TetR/AcrR family transcriptional regulator -
JN176_RS11865 2562793..2563617 + 825 WP_080588061.1 SAM-dependent methyltransferase -
JN176_RS11870 2563657..2563932 + 276 WP_038536176.1 hypothetical protein -
JN176_RS11875 2563990..2564379 + 390 WP_009956380.1 hypothetical protein Antitoxin
JN176_RS11880 2564404..2564982 + 579 WP_014941867.1 zeta toxin family protein Toxin
JN176_RS11885 2565002..2566069 - 1068 WP_014380064.1 DoxX family membrane protein -
JN176_RS11890 2566165..2566725 + 561 WP_158020468.1 pyrazinamidase PncA -
JN176_RS11895 2566725..2567525 + 801 WP_009956375.1 nuclear transport factor 2 family protein -
JN176_RS11900 2567537..2567887 - 351 WP_009956374.1 DoxX family protein -
JN176_RS11905 2568053..2569024 + 972 WP_014941870.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-138)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21005.20 Da        Isoelectric Point: 11.0232

>T38229 WP_014941867.1 NZ_AP024253:2564404-2564982 [Mycobacterium paraintracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGDAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTALRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMIIGSPDWPAWAPEILRSRWPD

Download         Length: 579 bp

>T38229 NZ_AP024253:2564404-2564982 [Mycobacterium paraintracellulare]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGATGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCTCCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGATTATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13512.89 Da        Isoelectric Point: 5.1828

>AT38229 WP_009956380.1 NZ_AP024253:2563990-2564379 [Mycobacterium paraintracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Download         Length: 390 bp

>AT38229 NZ_AP024253:2563990-2564379 [Mycobacterium paraintracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGACGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J9WIQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7TS83

References