38186

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/ParD(antitoxin)
Location 2742288..2743280 Replicon chromosome
Accession NZ_AP024240
Organism Mycobacterium paraintracellulare strain M001

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag MINTM021_RS12945 Protein ID WP_202377311.1
Coordinates 2742702..2743280 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag MINTM021_RS12940 Protein ID WP_201408208.1
Coordinates 2742288..2742677 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MINTM021_RS12915 2737741..2739744 + 2004 WP_202378128.1 phosphotransferase -
MINTM021_RS12920 2739741..2740286 + 546 WP_202377310.1 gluconokinase -
MINTM021_RS12925 2740310..2740921 - 612 WP_014384642.1 TetR/AcrR family transcriptional regulator -
MINTM021_RS12930 2741112..2741915 + 804 WP_202377378.1 SAM-dependent methyltransferase -
MINTM021_RS12935 2741955..2742230 + 276 WP_201408230.1 hypothetical protein -
MINTM021_RS12940 2742288..2742677 + 390 WP_201408208.1 hypothetical protein Antitoxin
MINTM021_RS12945 2742702..2743280 + 579 WP_202377311.1 zeta toxin family protein Toxin
MINTM021_RS12950 2743300..2744367 - 1068 WP_201408210.1 DoxX family membrane protein -
MINTM021_RS12955 2744463..2745023 + 561 WP_201408211.1 isochorismatase family protein -
MINTM021_RS12960 2745023..2745823 + 801 WP_201408212.1 nuclear transport factor 2 family protein -
MINTM021_RS12965 2745835..2746185 - 351 WP_201358466.1 DoxX family protein -
MINTM021_RS12970 2746351..2747322 + 972 WP_014941870.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-137)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21030.13 Da        Isoelectric Point: 10.8940

>T38186 WP_202377311.1 NZ_AP024240:2742702-2743280 [Mycobacterium paraintracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYDAAKIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTAVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSHWPD

Download         Length: 579 bp

>T38186 NZ_AP024240:2742702-2743280 [Mycobacterium paraintracellulare]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAGATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGAAAATCGCCGCCGCCACGCGGGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTCTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGCCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACAGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCACACTGGCCGGACTAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13483.85 Da        Isoelectric Point: 5.5504

>AT38186 WP_201408208.1 NZ_AP024240:2742288-2742677 [Mycobacterium paraintracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEV
SAAIDESLVHANYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Download         Length: 390 bp

>AT38186 NZ_AP024240:2742288-2742677 [Mycobacterium paraintracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAAGAAGGCGTGGTGTTCAACGCCGAGGTC
TCCGCGGCCATCGACGAAAGCCTGGTGCACGCCAACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References