Detailed information of TA system TA037881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2771734..2772372
• Replicon: chromosome
• Accession: NZ_AP024112
• Organism: Escherichia coli strain ECSC054

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7U9DHD1
• Locus tag: FE985_RS13090
• Protein ID: WP_000813795.1
• Coordinates: 2772196..2772372 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FE985_RS13085
• Protein ID: WP_076797675.1
• Coordinates: 2771734..2772150 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE985_RS13065 (2766886)	2766886..2767827	-	942	WP_001251315.1	ABC transporter permease	-
FE985_RS13070 (2767828)	2767828..2768841	-	1014	WP_001551095.1	ABC transporter ATP-binding protein	-
FE985_RS13075 (2768859)	2768859..2770004	-	1146	WP_001551094.1	ABC transporter substrate-binding protein	-
FE985_RS13080 (2770249)	2770249..2771655	-	1407	WP_001551093.1	PLP-dependent aminotransferase family protein	-
FE985_RS13085 (2771734)	2771734..2772150	-	417	WP_076797675.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
FE985_RS13090 (2772196)	2772196..2772372	-	177	WP_000813795.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
FE985_RS13095 (2772594)	2772594..2772824	+	231	WP_023910283.1	YncJ family protein	-
FE985_RS13100 (2772916)	2772916..2774877	-	1962	WP_001551090.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
FE985_RS13105 (2774950)	2774950..2775486	-	537	WP_001551089.1	DNA-binding transcriptional regulator SutR	-
FE985_RS13110 (2775578)	2775578..2776750	+	1173	WP_001551088.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-65)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6747.80 Da
• Isoelectric Point: 11.5666

>T37881 WP_000813795.1 NZ_AP024112:c2772372-2772196 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T37881 NZ_AP024112:c2772372-2772196 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15220.55 Da
• Isoelectric Point: 4.7386

>AT37881 WP_076797675.1 NZ_AP024112:c2772150-2771734 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT37881 NZ_AP024112:c2772150-2771734 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A7U9DHD1