Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4457290..4458071 Replicon chromosome
Accession NZ_AP023303
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4526

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5618_RS21835 Protein ID WP_000626099.1
Coordinates 4457290..4457781 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5618_RS21840 Protein ID WP_001110452.1
Coordinates 4457778..4458071 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5618_RS21795 (4452476) 4452476..4452718 - 243 WP_197603740.1 hypothetical protein -
K5618_RS21800 (4452715) 4452715..4453071 - 357 WP_033567083.1 hypothetical protein -
K5618_RS21805 (4453068) 4453068..4453940 - 873 WP_033567082.1 ParA family protein -
K5618_RS21810 (4454131) 4454131..4454208 - 78 Protein_4291 helix-turn-helix domain-containing protein -
K5618_RS21815 (4454299) 4454299..4454631 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5618_RS21820 (4454703) 4454703..4455080 + 378 WP_000916345.1 EthD family reductase -
K5618_RS21825 (4456113) 4456113..4456187 + 75 Protein_4294 porin family protein -
K5618_RS21830 (4456290) 4456290..4457042 + 753 WP_000842434.1 non-specific acid phosphatase -
K5618_RS21835 (4457290) 4457290..4457781 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5618_RS21840 (4457778) 4457778..4458071 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5618_RS21845 (4458388) 4458388..4458609 + 222 WP_001576552.1 hypothetical protein -
K5618_RS21850 (4458874) 4458874..4459749 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5618_RS21855 (4459746) 4459746..4460033 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5618_RS21860 (4460056) 4460056..4460271 + 216 WP_001595136.1 hypothetical protein -
K5618_RS21865 (4460279) 4460279..4460548 + 270 WP_010989096.1 hypothetical protein -
K5618_RS21870 (4460842) 4460842..4461747 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37387 WP_000626099.1 NZ_AP023303:c4457781-4457290 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37387 NZ_AP023303:c4457781-4457290 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37387 WP_001110452.1 NZ_AP023303:c4458071-4457778 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37387 NZ_AP023303:c4458071-4457778 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References