Detailed information of TA system TA036651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2382385..2383359
• Replicon: chromosome
• Accession: NZ_AP022952
• Organism: Bacillus cereus strain J39

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: L6483_RS12210
• Protein ID: WP_062923173.1
• Coordinates: 2382385..2383122 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: L6483_RS12215
• Protein ID: WP_062923165.1
• Coordinates: 2383234..2383359 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6483_RS12185 (BCJMU39_2366)	2377880..2378581	+	702	WP_236788434.1	hypothetical protein	-
L6483_RS12190 (BCJMU39_2367)	2378708..2379592	+	885	WP_062923162.1	hypothetical protein	-
L6483_RS12195	2379901..2380703	-	803	Protein_2326	thiamine pyrophosphate-binding protein	-
L6483_RS12200 (BCJMU39_2370)	2380810..2381292	+	483	WP_062923163.1	MarR family winged helix-turn-helix transcriptional regulator	-
L6483_RS12205 (BCJMU39_2371)	2381459..2382196	+	738	WP_062923164.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
L6483_RS12210 (BCJMU39_2372)	2382385..2383122	+	738	WP_062923173.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
L6483_RS12215 (BCJMU39_2373)	2383234..2383359	+	126	WP_062923165.1	hypothetical protein	Antitoxin
L6483_RS12220 (BCJMU39_2374)	2383433..2383609	+	177	WP_062923166.1	stage II sporulation protein SB	-
L6483_RS12225 (BCJMU39_2375)	2383628..2384017	-	390	WP_062923167.1	YxeA family protein	-
L6483_RS12230 (BCJMU39_2376)	2384234..2385703	+	1470	WP_062923168.1	beta-Ala-His dipeptidase	-
L6483_RS12235 (BCJMU39_2377)	2386285..2386755	-	471	WP_061530815.1	DUF5065 family protein	-
L6483_RS12240 (BCJMU39_2378)	2387209..2387868	+	660	WP_000876955.1	CatB-related O-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28351.03 Da
• Isoelectric Point: 8.3034

>T36651 WP_062923173.1 NZ_AP022952:2382385-2383122 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYIKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKTVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T36651 NZ_AP022952:2382385-2383122 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGTTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAGTTGTACGAAGAGAAGAAGCAACGGATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTCAATCCGGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAAGAATATATAAAAAGCTTAAACGCATTTTTAGATTCGTATGGTGAAAAGATTGGGGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGCTCACAATTTAGTATCATCGTTCCGTTTGA
ACATATTGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCGGCAAAAACTGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4938.34 Da
• Isoelectric Point: 3.9150

>AT36651 WP_062923165.1 NZ_AP022952:2383234-2383359 [Bacillus cereus]
VIKDYDNDFFKEENEDTTDFSLIKGDTLQQVEELEDELKRK

Nucleotide

• Length: 126 bp

>AT36651 NZ_AP022952:2383234-2383359 [Bacillus cereus]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGAAAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA