Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2325235..2325848 Replicon chromosome
Accession NZ_AP022608
Organism Mycolicibacterium gadium strain JCM 12688

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N36_RS11550 Protein ID WP_163686635.1
Coordinates 2325235..2325639 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N36_RS11555 Protein ID WP_179964762.1
Coordinates 2325639..2325848 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N36_RS11530 2320797..2321807 - 1011 WP_163686631.1 MCE family protein -
G6N36_RS11535 2321804..2322871 - 1068 WP_163686632.1 MCE family protein -
G6N36_RS11540 2322874..2323734 - 861 WP_163686633.1 ABC transporter permease -
G6N36_RS11545 2323739..2324725 - 987 WP_163686634.1 ABC transporter permease -
G6N36_RS11550 2325235..2325639 - 405 WP_163686635.1 PIN domain nuclease Toxin
G6N36_RS11555 2325639..2325848 - 210 WP_179964762.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N36_RS11565 2326507..2327475 - 969 WP_163686637.1 glycine betaine ABC transporter substrate-binding protein -
G6N36_RS11570 2327481..2328245 - 765 WP_163690621.1 ABC transporter permease -
G6N36_RS11575 2328263..2329381 - 1119 WP_163690622.1 betaine/proline/choline family ABC transporter ATP-binding protein -
G6N36_RS11580 2329461..2330108 - 648 WP_163690623.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14638.73 Da        Isoelectric Point: 4.7462

>T36346 WP_163686635.1 NZ_AP022608:c2325639-2325235 [Mycolicibacterium gadium]
MILIDTSAWIEYLRATGSAAAIEVRRLLSTDADRVVMCEPIAMEILSGAVDDDKYAKLEQLVNGLPSLKIDDSVDYRSAA
AIYRAARRTGQTIRSINDCLIAALSIRHGASIIHRDADFEVIAAITGLEAESFR

Download         Length: 405 bp

>T36346 NZ_AP022608:c2325639-2325235 [Mycolicibacterium gadium]
ATGATCCTGATCGATACGTCGGCCTGGATCGAATACCTTCGCGCAACCGGGTCGGCCGCCGCGATCGAGGTGCGCCGACT
GCTGTCAACCGACGCGGATCGGGTCGTTATGTGCGAGCCCATCGCGATGGAGATATTGTCCGGCGCAGTCGATGACGACA
AATACGCCAAGCTCGAGCAGCTTGTGAATGGGCTACCGTCGCTGAAAATCGATGACTCAGTCGACTATCGCAGTGCTGCA
GCCATCTACCGGGCGGCCCGACGCACCGGTCAGACAATCCGAAGTATCAATGACTGTTTGATTGCCGCTTTGTCGATTCG
CCACGGCGCCAGCATCATTCACCGCGATGCAGACTTTGAGGTCATCGCGGCGATCACAGGTCTTGAGGCCGAGTCATTCC
GCTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7943.09 Da        Isoelectric Point: 4.7420

>AT36346 WP_179964762.1 NZ_AP022608:c2325848-2325639 [Mycolicibacterium gadium]
MSRTNIDIDDELVAQVMRRYGIPTKKQAVDLALRRLVGVPLSREFLLSLEGVGWDADLDDIRRERPSEF

Download         Length: 210 bp

>AT36346 NZ_AP022608:c2325848-2325639 [Mycolicibacterium gadium]
ATGTCGCGCACGAATATCGATATTGATGACGAGCTCGTCGCTCAGGTGATGCGAAGATACGGGATTCCCACCAAGAAGCA
GGCCGTCGACCTGGCTCTACGGCGGCTGGTTGGCGTCCCGTTGAGTCGGGAGTTTCTGCTAAGTCTGGAAGGCGTCGGAT
GGGACGCCGACCTTGACGACATTCGGCGAGAGCGACCCAGCGAATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References