Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1678334..1678898 Replicon chromosome
Accession NZ_AP022606
Organism Mycobacterium branderi strain JCM 12687

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N47_RS08595 Protein ID WP_083133554.1
Coordinates 1678334..1678684 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N47_RS08600 Protein ID WP_083133555.1
Coordinates 1678668..1678898 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N47_RS08565 1673716..1674132 - 417 WP_083133549.1 GtrA family protein -
G6N47_RS08570 1674159..1674644 - 486 WP_083133550.1 GreA/GreB family elongation factor -
G6N47_RS08575 1674761..1674955 - 195 WP_083133612.1 CsbD family protein -
G6N47_RS08580 1675117..1676352 - 1236 WP_083133551.1 threonine/serine exporter family protein -
G6N47_RS08585 1676339..1677616 - 1278 WP_083133552.1 hypothetical protein -
G6N47_RS08590 1677760..1678329 - 570 WP_083133553.1 isoprenylcysteine carboxylmethyltransferase family protein -
G6N47_RS08595 1678334..1678684 - 351 WP_083133554.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N47_RS08600 1678668..1678898 - 231 WP_083133555.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N47_RS08605 1678937..1679767 - 831 WP_083133556.1 ABC transporter permease -
G6N47_RS08610 1679764..1680651 - 888 WP_083133557.1 glycosyltransferase family 2 protein -
G6N47_RS08615 1680648..1681439 - 792 WP_083133558.1 ABC transporter ATP-binding protein -
G6N47_RS08620 1681450..1681980 - 531 WP_179966436.1 bacterial proteasome activator family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12630.52 Da        Isoelectric Point: 11.3028

>T36333 WP_083133554.1 NZ_AP022606:c1678684-1678334 [Mycobacterium branderi]
VMRRGEIWQVDFDPARGSEANKHRPAVIVSNDRANATAARLGRGVVTVVPVTSNIAKVYPFQVLLPAAGTGLAVDSKAQA
EQIRSVATQRLQRRIGRLSPVELAQLDDALRLHLEL

Download         Length: 351 bp

>T36333 NZ_AP022606:c1678684-1678334 [Mycobacterium branderi]
GTGATGCGCCGCGGTGAGATCTGGCAGGTCGACTTCGACCCTGCTCGCGGCAGCGAAGCCAACAAGCATCGGCCGGCGGT
GATCGTCAGCAACGACCGGGCCAACGCGACAGCTGCCCGACTTGGCCGTGGCGTAGTGACCGTGGTGCCGGTCACGAGCA
ATATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGCCGGCGGCCGGCACGGGTCTCGCGGTCGATTCCAAAGCGCAGGCC
GAACAGATCAGATCTGTTGCGACACAACGTCTTCAGCGACGGATTGGTCGGCTCTCACCGGTCGAGCTTGCCCAACTAGA
CGACGCGCTGCGTCTGCACCTCGAGCTGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8464.27 Da        Isoelectric Point: 3.9221

>AT36333 WP_083133555.1 NZ_AP022606:c1678898-1678668 [Mycobacterium branderi]
MKLSVSLPEEDVHVLDAYVERAGLPSRSAGLQRAIRMLRYPTLEDDYDEAWTEWSAAAEDDVWEAAADDGLGDAPR

Download         Length: 231 bp

>AT36333 NZ_AP022606:c1678898-1678668 [Mycobacterium branderi]
ATGAAGCTGAGTGTCAGCCTGCCCGAGGAAGACGTCCACGTGCTGGACGCCTATGTCGAGCGGGCGGGATTACCGTCACG
GTCGGCAGGTCTGCAACGAGCAATTCGGATGCTTCGCTACCCCACGTTGGAAGACGACTATGACGAGGCTTGGACGGAGT
GGTCGGCTGCCGCCGAGGACGACGTGTGGGAGGCCGCTGCGGACGACGGGCTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References