Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1128753..1129438 Replicon chromosome
Accession NZ_AP022606
Organism Mycobacterium branderi strain JCM 12687

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N47_RS05960 Protein ID WP_083131786.1
Coordinates 1129010..1129438 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N47_RS05955 Protein ID WP_083131787.1
Coordinates 1128753..1129007 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N47_RS05940 1124982..1126823 - 1842 WP_083131790.1 type VII secretion AAA-ATPase EccA -
G6N47_RS05945 1127288..1127674 + 387 WP_083131789.1 PPE family protein -
G6N47_RS05950 1127732..1128637 - 906 WP_083131788.1 class I SAM-dependent methyltransferase -
G6N47_RS05955 1128753..1129007 + 255 WP_083131787.1 ribbon-helix-helix protein, CopG family Antitoxin
G6N47_RS05960 1129010..1129438 + 429 WP_083131786.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N47_RS05965 1129439..1130347 - 909 WP_083131785.1 DUF2236 domain-containing protein -
G6N47_RS05970 1130420..1131067 + 648 WP_083131784.1 TetR/AcrR family transcriptional regulator -
G6N47_RS05975 1131064..1131639 - 576 WP_083131783.1 VOC family protein -
G6N47_RS05980 1131766..1132413 + 648 WP_083131782.1 TetR/AcrR family transcriptional regulator -
G6N47_RS05985 1132415..1133536 + 1122 WP_083131781.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-132)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15627.85 Da        Isoelectric Point: 6.2100

>T36332 WP_083131786.1 NZ_AP022606:1129010-1129438 [Mycobacterium branderi]
MFLLDVNVVLAAHRGDHPDHPTVRPWFDQLLAGDEPFGVPNVVWASFLRLATNRRIFEIPTPLAAAFAFIEATNAQPHHL
PANPGPRHLTLLREIAEEADASGDLIPDAVLAAIAAEHHCAVVTLDRDFARFTAVRHIRPTV

Download         Length: 429 bp

>T36332 NZ_AP022606:1129010-1129438 [Mycobacterium branderi]
ATGTTCCTTCTCGACGTCAACGTGGTGCTGGCCGCTCACCGGGGTGACCACCCGGATCACCCGACTGTCCGCCCCTGGTT
CGATCAACTGCTCGCTGGTGACGAGCCCTTTGGCGTGCCGAACGTGGTGTGGGCGTCGTTTCTTCGATTGGCGACAAATC
GCCGGATCTTTGAGATCCCGACACCGCTAGCCGCGGCATTCGCCTTCATCGAGGCGACCAATGCCCAACCACACCATCTC
CCCGCGAACCCCGGCCCACGACACCTGACGCTGCTCCGCGAAATCGCCGAGGAGGCCGATGCCTCCGGCGACCTGATTCC
CGACGCGGTGCTCGCCGCAATCGCCGCCGAACATCACTGTGCAGTGGTAACTCTCGATCGCGACTTCGCCCGGTTCACCG
CGGTGCGCCACATCCGGCCGACGGTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9211.53 Da        Isoelectric Point: 11.2826

>AT36332 WP_083131787.1 NZ_AP022606:1128753-1129007 [Mycobacterium branderi]
MRTTVSISDELLAAAKRRARERGQSLGAVIEDALRRELAAAPDSKPRPKVPIFHGTGPRPGLELTSNRALAEVLDEGLDL
NRRR

Download         Length: 255 bp

>AT36332 NZ_AP022606:1128753-1129007 [Mycobacterium branderi]
ATGCGCACCACGGTATCGATCTCTGACGAACTCCTGGCGGCCGCCAAGCGGCGGGCACGCGAACGAGGACAATCGCTCGG
GGCGGTGATCGAGGATGCCCTTCGCCGCGAACTCGCCGCGGCGCCCGACTCCAAGCCGCGACCGAAAGTCCCGATATTCC
ACGGCACCGGCCCACGGCCGGGCCTGGAGTTGACCTCCAACCGCGCCTTGGCCGAAGTTCTCGACGAAGGTCTCGACCTG
AACAGGCGTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References