Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3798658..3799277 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N24_RS17480 Protein ID WP_085157349.1
Coordinates 3798658..3799065 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N24_RS17485 Protein ID WP_085157346.1
Coordinates 3799062..3799277 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS17465 3795350..3796039 + 690 WP_085157358.1 LpqN/LpqT family lipoprotein -
G6N24_RS17470 3796066..3797775 + 1710 WP_085157355.1 hypothetical protein -
G6N24_RS17475 3797807..3798631 + 825 WP_139822220.1 DUF3298 domain-containing protein -
G6N24_RS17480 3798658..3799065 - 408 WP_085157349.1 PIN domain-containing protein Toxin
G6N24_RS17485 3799062..3799277 - 216 WP_085157346.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N24_RS17490 3799384..3799887 + 504 WP_085157343.1 hypothetical protein -
G6N24_RS17495 3799832..3800629 - 798 WP_085157615.1 Mut7-C ubiquitin/RNAse domain-containing protein -
G6N24_RS17500 3800653..3801759 - 1107 WP_085157340.1 galactokinase -
G6N24_RS17505 3801756..3802850 - 1095 WP_085157335.1 galactose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-118)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14697.78 Da        Isoelectric Point: 4.5164

>T36236 WP_085157349.1 NZ_AP022581:c3799065-3798658 [Mycobacterium lacus]
VIVDTSALLAFFDVAEPDHAAVTGCIDRSEEVLVVSPYVVAELDYLIATRVGVDAELAVLRELASGAWELAEFGAAELEQ
AADIVKKYRDQRIGIADASNVVLADRYRTRTIVTLDRRHFTVLRPVGGGRFAVIP

Download         Length: 408 bp

>T36236 NZ_AP022581:c3799065-3798658 [Mycobacterium lacus]
GTGATCGTCGACACAAGTGCGCTGCTTGCCTTTTTCGATGTGGCCGAGCCAGACCATGCGGCCGTGACCGGCTGCATCGA
TAGATCCGAGGAAGTACTCGTCGTTTCGCCGTATGTCGTCGCGGAACTCGACTATCTCATCGCCACCCGGGTAGGGGTTG
ATGCCGAGCTCGCGGTCCTGCGCGAACTCGCCAGCGGGGCATGGGAGCTCGCCGAATTCGGTGCCGCCGAGTTGGAGCAA
GCGGCCGACATTGTAAAGAAATATCGCGACCAGCGCATTGGGATCGCGGATGCGTCCAACGTGGTGCTGGCTGATCGGTA
CCGCACGCGCACGATCGTCACCCTGGACCGCCGCCACTTCACGGTGTTGCGGCCGGTTGGCGGTGGGCGGTTCGCGGTCA
TTCCGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7665.72 Da        Isoelectric Point: 10.6707

>AT36236 WP_085157346.1 NZ_AP022581:c3799277-3799062 [Mycobacterium lacus]
VDKTTVYLPDDLKAAVKRAARQRGVSEAEVIRDSIRMAVGAARPAPRGGLYSGSQPVARRVDELLDGFGQR

Download         Length: 216 bp

>AT36236 NZ_AP022581:c3799277-3799062 [Mycobacterium lacus]
GTGGATAAGACAACGGTCTACTTGCCGGACGATCTCAAAGCGGCCGTGAAGCGCGCGGCCCGGCAGCGTGGGGTCTCCGA
GGCCGAGGTCATCAGGGATTCCATCCGGATGGCGGTAGGCGCTGCTAGGCCGGCGCCGCGCGGGGGCCTGTACTCGGGCT
CGCAGCCGGTTGCCCGGCGCGTCGACGAGCTTCTGGACGGCTTTGGTCAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References