Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4257103..4257788 Replicon chromosome
Accession NZ_AP022575
Organism Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N20_RS19280 Protein ID WP_083047199.1
Coordinates 4257103..4257534 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N20_RS19285 Protein ID WP_083047305.1
Coordinates 4257531..4257788 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N20_RS19255 4252400..4253431 + 1032 WP_083047207.1 acyl-CoA/acyl-ACP dehydrogenase -
G6N20_RS19260 4253416..4254579 + 1164 WP_083047205.1 acyl-CoA dehydrogenase family protein -
G6N20_RS19265 4254576..4255520 + 945 WP_083047203.1 bifunctional MaoC family dehydratase/OB-fold nucleic acid binding domain-containing protein -
G6N20_RS19270 4255517..4255918 + 402 WP_083047307.1 MaoC family dehydratase -
G6N20_RS19275 4255918..4257087 + 1170 WP_083047201.1 lipid-transfer protein -
G6N20_RS19280 4257103..4257534 - 432 WP_083047199.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N20_RS19285 4257531..4257788 - 258 WP_083047305.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N20_RS19290 4257847..4258710 - 864 WP_083047197.1 MaoC family dehydratase N-terminal domain-containing protein -
G6N20_RS19295 4258712..4260403 - 1692 WP_083047303.1 3-oxosteroid 1-dehydrogenase -
G6N20_RS19300 4260486..4261271 + 786 WP_083047196.1 2-keto-4-pentenoate hydratase -
G6N20_RS19305 4261306..4262217 + 912 WP_083047301.1 acetaldehyde dehydrogenase (acetylating) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15694.81 Da        Isoelectric Point: 4.8784

>T36212 WP_083047199.1 NZ_AP022575:c4257534-4257103 [Mycobacterium shinjukuense]
MRLLDLNILIYAIDESSPRHGAARGWLEETLSGSATVAFPWHVLVGFVRLSTRATVFERPLTVDESFDIVDGWLEQPCVT
VVHPTDRHAVVLRGLLAPFGTAGNLTSDAHLAALSLEHGAELCSTDIDFSRFSGVRWVDPLQT

Download         Length: 432 bp

>T36212 NZ_AP022575:c4257534-4257103 [Mycobacterium shinjukuense]
ATGAGACTGCTCGATCTCAATATCCTCATCTATGCGATCGACGAGTCGTCACCCCGTCATGGGGCGGCACGCGGTTGGCT
TGAAGAAACCTTGTCCGGTTCGGCAACCGTCGCTTTCCCGTGGCACGTCCTCGTCGGATTCGTCCGGCTATCGACGCGCG
CGACGGTGTTTGAGCGGCCGTTGACGGTCGACGAGTCCTTCGACATCGTTGACGGATGGCTGGAGCAACCGTGTGTAACG
GTCGTCCATCCGACGGATCGCCACGCGGTCGTCCTGCGCGGGCTGCTCGCTCCGTTTGGTACGGCGGGAAATCTAACCAG
CGATGCCCATCTGGCGGCCTTGTCGCTCGAGCACGGCGCCGAACTGTGTTCCACCGATATCGATTTCAGCCGATTCTCTG
GGGTGCGCTGGGTCGATCCGCTACAAACGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9317.65 Da        Isoelectric Point: 11.0787

>AT36212 WP_083047305.1 NZ_AP022575:c4257788-4257531 [Mycobacterium shinjukuense]
MRTTVTLDPDVVAALRRTARERGTSFKAVLNDAVRRGLSGEPTGRRYHTPSRDLGLRAGFDIDKALALAAADEDAEVLRK
LALRK

Download         Length: 258 bp

>AT36212 NZ_AP022575:c4257788-4257531 [Mycobacterium shinjukuense]
ATGAGAACCACCGTGACGCTGGACCCCGATGTTGTCGCGGCGCTGCGGCGCACAGCCCGCGAGCGGGGAACGTCCTTCAA
AGCCGTGTTGAACGATGCGGTGCGGCGCGGCTTAAGTGGCGAGCCCACCGGGCGGCGCTACCACACGCCGAGTCGCGACC
TGGGACTGCGGGCGGGATTCGACATCGACAAGGCGTTGGCATTGGCCGCGGCGGACGAAGACGCAGAGGTCTTGCGCAAG
CTTGCGCTTCGCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References