Detailed information of TA system TA035632

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4864842..4865355
• Replicon: chromosome
• Accession: NZ_AP022412
• Organism: Klebsiella quasipneumoniae strain STW0522-39

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JLF46_RS23790
• Protein ID: WP_064190102.1
• Coordinates: 4864842..4865123 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: JLF46_RS23795
• Protein ID: WP_002886901.1
• Coordinates: 4865113..4865355 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JLF46_RS23775	4859884..4861539	+	1656	WP_048322789.1	alpha,alpha-phosphotrehalase	-
JLF46_RS23780	4861925..4864063	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
JLF46_RS23785	4864374..4864838	+	465	WP_064190101.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JLF46_RS23790	4864842..4865123	-	282	WP_064190102.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JLF46_RS23795	4865113..4865355	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JLF46_RS23800	4865433..4867343	-	1911	WP_064795190.1	BglG family transcription antiterminator	-
JLF46_RS23805	4867366..4868517	-	1152	WP_087832357.1	lactonase family protein	-
JLF46_RS23810	4868584..4869324	-	741	WP_017900574.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11031.81 Da
• Isoelectric Point: 10.1752

>T35632 WP_064190102.1 NZ_AP022412:c4865123-4864842 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNNLQQIMQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T35632 NZ_AP022412:c4865123-4864842 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGCTTGGCGAGACGGTCAAAAAACAGTTCAAAAA
TAATCTCCAGCAGATTATGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCAAGC
TTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAAAGA
GAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT35632 WP_002886901.1 NZ_AP022412:c4865355-4865113 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT35632 NZ_AP022412:c4865355-4865113 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGACTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGTCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0