Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 368951..370668 Replicon chromosome
Accession NZ_AP022318
Organism Burkholderia sp. THE68

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BTHE68_RS27625 Protein ID WP_162069492.1
Coordinates 369808..370668 (-) Length 287 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag BTHE68_RS27620 Protein ID WP_162069491.1
Coordinates 368951..369811 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTHE68_RS27600 364161..365651 - 1491 WP_162069487.1 aldehyde dehydrogenase -
BTHE68_RS27605 365668..366492 - 825 WP_162069488.1 aspartate dehydrogenase -
BTHE68_RS27610 366485..368152 - 1668 WP_162069489.1 thiamine pyrophosphate-binding protein -
BTHE68_RS27615 368145..368954 - 810 WP_162069490.1 SDR family oxidoreductase -
BTHE68_RS27620 368951..369811 - 861 WP_162069491.1 IclR family transcriptional regulator Antitoxin
BTHE68_RS27625 369808..370668 - 861 WP_162069492.1 alpha/beta fold hydrolase Toxin
BTHE68_RS27630 370676..371203 - 528 WP_162069493.1 cupin domain-containing protein -
BTHE68_RS27635 371233..371985 - 753 WP_162069494.1 SDR family oxidoreductase -
BTHE68_RS27640 371978..373042 - 1065 WP_162069495.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BTHE68_RS27645 373060..373368 - 309 WP_061177006.1 hypothetical protein -
BTHE68_RS27650 373370..373687 - 318 WP_035500201.1 non-heme iron oxygenase ferredoxin subunit -
BTHE68_RS27655 374129..375202 + 1074 WP_162069496.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(36-265)

Antitoxin

Transcription regulator IclR, N-terminal

(21-69)


Sequences

Toxin        


Download         Length: 287 a.a.        Molecular weight: 30353.71 Da        Isoelectric Point: 6.6519

>T35314 WP_162069492.1 NZ_AP022318:c370668-369808 [Burkholderia sp. THE68]
MYIETLASFADMRIDTAHGITGYREAGAMHLRTLPVVLLHGIGSGAASWVRQLDVLGAKRRVLAWDAPGYGASTRVTSES
PMACDYAIALSAWLDALGVTRCVLVGHSLGAIIAGSFAADMPERVAGLLLISPAAGYGAASKDVRESRRDARLKMLAELG
PQRLAQERSANMVSQYADETAREWVRWNMARIVPEGYAQATHLLANAHLAADIARFHGRIAVAVGAEDTITPPDACAPIA
QAAHVSLQVIPRAGHAGYVESPAAYTALIDAFCQGIECHMNDGVTP

Download         Length: 861 bp

>T35314 NZ_AP022318:c370668-369808 [Burkholderia sp. THE68]
ATGTACATCGAGACGCTCGCCTCGTTCGCCGATATGCGGATCGACACCGCGCACGGCATCACGGGTTATCGCGAAGCAGG
TGCAATGCACCTGCGCACCCTGCCCGTCGTGTTGCTGCATGGGATCGGCTCGGGCGCGGCGTCGTGGGTGCGGCAACTCG
ACGTGCTCGGTGCGAAGCGTCGCGTGCTCGCGTGGGATGCGCCGGGATATGGCGCGTCCACTCGCGTGACGAGTGAATCG
CCGATGGCATGCGATTACGCGATCGCACTGTCAGCGTGGCTCGATGCGCTGGGCGTCACGCGCTGCGTGCTCGTCGGTCA
TTCGCTGGGCGCGATCATCGCGGGTTCGTTCGCCGCCGACATGCCCGAGCGCGTCGCGGGCCTGTTGCTGATATCTCCCG
CGGCGGGTTATGGCGCTGCATCGAAGGACGTGCGCGAGTCCAGACGCGACGCACGTTTGAAGATGCTCGCCGAACTCGGC
CCGCAACGACTCGCGCAAGAACGCAGCGCGAACATGGTCTCGCAATACGCCGATGAAACCGCACGCGAATGGGTGCGCTG
GAACATGGCGCGCATCGTGCCCGAGGGCTACGCGCAAGCGACGCATCTGCTCGCGAACGCGCATCTCGCAGCGGATATCG
CGCGCTTTCACGGACGTATCGCGGTGGCGGTGGGCGCAGAAGACACGATCACGCCGCCCGACGCTTGCGCACCCATCGCG
CAGGCCGCGCACGTCAGCCTGCAAGTGATTCCGCGTGCCGGACATGCGGGCTATGTCGAATCGCCCGCTGCCTACACGGC
GCTGATCGATGCGTTTTGCCAGGGCATCGAATGTCACATGAACGACGGAGTAACACCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31565.11 Da        Isoelectric Point: 6.3650

>AT35314 WP_162069491.1 NZ_AP022318:c369811-368951 [Burkholderia sp. THE68]
MTSLAPEEADKSEPTYIVPGLERGLKILTEFSPREPVLGAPELSRRLGIPRTTVFRLLQTLESLGFLERADKDRNYRLGV
AVLRLGFEYLSSLELTDLGLPIIEALRDATGLTSHILIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLPAHATTHGHVLM
GDLSLDELRVLYPEQPLERFTKSTPETVEELYERVKEDAERGYATSQSSFERGISVVTAPVRNDTGRIVAVITTTIPRPE
IDAALLESGLIDKVREAADALSMRLNYRPAARASASSRYMKSLGLQ

Download         Length: 861 bp

>AT35314 NZ_AP022318:c369811-368951 [Burkholderia sp. THE68]
ATGACATCACTCGCCCCAGAAGAAGCCGACAAGAGCGAGCCGACTTATATCGTGCCGGGCCTCGAACGCGGACTGAAGAT
TCTTACCGAGTTCTCGCCGCGCGAACCCGTGCTCGGCGCGCCCGAATTGTCGCGGCGTCTCGGCATTCCACGCACGACGG
TTTTCCGTCTGCTTCAGACACTCGAATCGCTCGGCTTTCTGGAACGCGCGGACAAGGACCGCAACTATCGCCTCGGCGTC
GCGGTGCTGCGTCTCGGCTTCGAATACCTGAGTTCGCTCGAACTGACCGATCTCGGCCTGCCGATCATCGAAGCGTTGCG
CGATGCGACCGGCCTCACGAGTCACATCCTCATTCGCGATGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAGAGTCACG
CGCCGATCTTCAGCTCGGTGAAGGTGAACGTCGGCACGCGACTGCCCGCGCATGCGACCACGCATGGTCATGTATTGATG
GGCGATCTCTCGCTCGATGAACTGCGCGTGCTCTATCCGGAACAACCTCTGGAGCGCTTCACGAAGTCGACGCCCGAAAC
CGTGGAAGAACTTTACGAACGCGTGAAGGAAGACGCCGAACGCGGCTATGCGACGAGTCAATCGTCGTTCGAGCGCGGCA
TTTCGGTCGTCACCGCGCCGGTTCGCAACGACACGGGGCGCATCGTCGCCGTCATCACGACGACGATCCCGCGTCCCGAG
ATCGACGCCGCGCTGCTCGAAAGCGGCCTCATCGACAAAGTTCGCGAAGCCGCCGACGCGCTCTCCATGCGTCTCAACTA
TCGTCCGGCCGCGCGTGCTTCAGCGTCGAGCCGCTATATGAAGTCTCTGGGGTTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References