Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 960088..960755 Replicon chromosome
Accession NZ_AP022315
Organism Burkholderia sp. THE68

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BTHE68_RS04525 Protein ID WP_162065321.1
Coordinates 960088..960504 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BTHE68_RS04530 Protein ID WP_162066787.1
Coordinates 960501..960755 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTHE68_RS04500 955531..956535 + 1005 WP_162066786.1 beta-propeller fold lactonase family protein -
BTHE68_RS04505 956625..957644 + 1020 WP_162065317.1 sterol desaturase family protein -
BTHE68_RS04510 957723..958574 + 852 WP_162065318.1 EI24 domain-containing protein -
BTHE68_RS04515 958591..959409 + 819 WP_162065319.1 competence/damage-inducible protein A -
BTHE68_RS04520 959406..960104 + 699 WP_162065320.1 copper homeostasis protein CutC -
BTHE68_RS04525 960088..960504 - 417 WP_162065321.1 type II toxin-antitoxin system VapC family toxin Toxin
BTHE68_RS04530 960501..960755 - 255 WP_162066787.1 Arc family DNA-binding protein Antitoxin
BTHE68_RS04535 960822..961286 - 465 WP_162065322.1 rhodanese-like domain-containing protein -
BTHE68_RS04540 961645..963060 + 1416 WP_061119874.1 type I glutamate--ammonia ligase -
BTHE68_RS04545 963223..964365 + 1143 WP_162066788.1 PAS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14900.33 Da        Isoelectric Point: 4.5156

>T35309 WP_162065321.1 NZ_AP022315:c960504-960088 [Burkholderia sp. THE68]
MILLDTNVVSELFRLTPDMKVIEWLDAQPLQTLYLSAITVAEMRWGVAQIPAGKRRDALNAKLEEGLMPLVATRVLPFDI
DCAQSYADLMTKARAEGRGIALADGLIAAVAAAKGLAVATRDTSPFEAAGLTVFNPWD

Download         Length: 417 bp

>T35309 NZ_AP022315:c960504-960088 [Burkholderia sp. THE68]
ATGATTTTGCTGGATACGAACGTGGTGTCCGAGCTGTTTCGTCTGACCCCCGATATGAAGGTCATCGAATGGCTCGATGC
ACAACCGCTGCAGACGCTCTATCTGTCCGCCATCACCGTGGCGGAAATGCGATGGGGCGTCGCACAAATCCCTGCGGGCA
AGCGACGCGATGCGCTGAACGCGAAGCTCGAAGAAGGCTTGATGCCGCTGGTAGCCACACGCGTATTGCCGTTTGACATC
GACTGCGCTCAAAGCTACGCCGACCTCATGACAAAGGCCCGCGCAGAAGGACGCGGCATCGCTCTGGCGGATGGCCTCAT
CGCCGCAGTCGCCGCGGCGAAAGGTCTCGCCGTCGCCACTCGCGACACATCGCCTTTCGAGGCCGCCGGTTTGACGGTCT
TCAACCCCTGGGACTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9406.72 Da        Isoelectric Point: 7.2069

>AT35309 WP_162066787.1 NZ_AP022315:c960755-960501 [Burkholderia sp. THE68]
MAMLTVRNLPDEVHRALRLRAAEHGRSTEAEVRDILEAAVKPEGRVKLGSFLTGFGREAGLSDREFAIFENIRDRTPAKP
VSFE

Download         Length: 255 bp

>AT35309 NZ_AP022315:c960755-960501 [Burkholderia sp. THE68]
ATGGCAATGTTGACTGTACGGAACTTGCCTGACGAGGTACACCGGGCGCTACGGTTGCGCGCGGCGGAACACGGCCGAAG
CACCGAGGCAGAGGTACGCGACATACTGGAAGCAGCGGTCAAGCCGGAAGGACGCGTGAAACTCGGCTCGTTTCTGACCG
GATTTGGCCGTGAAGCGGGTTTGAGCGATCGCGAGTTCGCCATTTTCGAAAACATCCGTGACCGGACCCCGGCCAAGCCC
GTGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References