Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1457634..1458211 Replicon chromosome
Accession NZ_AP022256
Organism Klebsiella sp. WP8-S18-ESBL-06

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag H7R76_RS06910 Protein ID WP_182967319.1
Coordinates 1457634..1457963 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag H7R76_RS06915 Protein ID WP_182967321.1
Coordinates 1457960..1458211 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R76_RS06880 1453196..1454095 - 900 WP_182967313.1 oxygen-dependent coproporphyrinogen oxidase -
H7R76_RS06885 1454095..1454964 - 870 WP_106924160.1 N-acetylmuramoyl-L-alanine amidase AmiA -
H7R76_RS06890 1455178..1455603 + 426 WP_181357945.1 GNAT family acetyltransferase -
H7R76_RS06895 1455590..1456039 + 450 WP_182967315.1 DUF2919 domain-containing protein -
H7R76_RS06900 1456101..1456676 + 576 WP_182967317.1 RpoE-regulated lipoprotein -
H7R76_RS06905 1456774..1457673 + 900 WP_106924164.1 Dyp-type peroxidase -
H7R76_RS06910 1457634..1457963 - 330 WP_182967319.1 Txe/YoeB family addiction module toxin Toxin
H7R76_RS06915 1457960..1458211 - 252 WP_182967321.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H7R76_RS06920 1458458..1459474 + 1017 WP_106924167.1 sulfate ABC transporter substrate-binding protein -
H7R76_RS06925 1459474..1460307 + 834 WP_182967323.1 sulfate/thiosulfate ABC transporter permease CysT -
H7R76_RS06930 1460307..1461182 + 876 WP_182967325.1 sulfate/thiosulfate ABC transporter permease CysW -
H7R76_RS06935 1461172..1462266 + 1095 WP_035897287.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12672.53 Da        Isoelectric Point: 9.6743

>T35094 WP_182967319.1 NZ_AP022256:c1457963-1457634 [Klebsiella sp. WP8-S18-ESBL-06]
VKLIWSAQAWDDYLYWQDTDKSMIKKINELIRAIKRTPFVGKGKPEPLKFDLAGFWSRRITLEHRLVYKLDNDALLVAAC
RYHHQTARFMASEENAPYNATNLSSEGAK

Download         Length: 330 bp

>T35094 NZ_AP022256:c1457963-1457634 [Klebsiella sp. WP8-S18-ESBL-06]
GTGAAACTTATCTGGTCAGCACAGGCATGGGACGATTATCTGTACTGGCAAGATACGGATAAGAGCATGATAAAAAAGAT
AAACGAGCTTATCAGGGCGATTAAACGCACGCCCTTTGTCGGCAAAGGTAAGCCAGAACCGCTGAAATTTGATCTGGCGG
GATTTTGGTCCCGCCGGATCACATTAGAGCATCGACTTGTCTACAAACTTGATAACGATGCTCTACTGGTTGCGGCATGC
CGGTATCACCATCAGACGGCCCGTTTTATGGCATCTGAAGAGAATGCACCTTACAACGCCACTAACTTATCCAGCGAAGG
CGCAAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9400.76 Da        Isoelectric Point: 4.8004

>AT35094 WP_182967321.1 NZ_AP022256:c1458211-1457960 [Klebsiella sp. WP8-S18-ESBL-06]
MRIISDSEARQNLSTTLRQVTEDRAPIIITQQNGKACVLMSLEEYRSLEETAYLMRSPANAGRLMDAIEELKTGKGIQRD
LME

Download         Length: 252 bp

>AT35094 NZ_AP022256:c1458211-1457960 [Klebsiella sp. WP8-S18-ESBL-06]
ATGAGAATAATCAGCGATAGCGAAGCCCGGCAAAACCTATCCACAACGCTACGGCAAGTAACGGAAGATCGCGCCCCTAT
TATCATCACCCAACAAAACGGTAAGGCATGCGTGCTGATGTCGCTCGAAGAATACCGTTCGCTGGAAGAAACCGCTTATC
TGATGCGATCACCCGCAAATGCCGGACGACTCATGGATGCGATTGAGGAGCTAAAAACTGGAAAAGGTATCCAAAGGGAT
TTGATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References