Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3421170..3421875 Replicon chromosome
Accession NZ_AP022069
Organism Escherichia coli strain WP4-W18-ESBL-09

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag H7R28_RS16525 Protein ID WP_000539521.1
Coordinates 3421170..3421556 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H7R28_RS16530 Protein ID WP_001280945.1
Coordinates 3421546..3421875 (+) Length 110 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R28_RS16505 3417174..3417800 + 627 WP_020233670.1 glutathione S-transferase GstB -
H7R28_RS16510 3417797..3418912 - 1116 WP_000555050.1 aldose sugar dehydrogenase YliI -
H7R28_RS16515 3419023..3419406 - 384 WP_000497137.1 biofilm formation regulator BssR -
H7R28_RS16520 3419619..3420944 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
H7R28_RS16525 3421170..3421556 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7R28_RS16530 3421546..3421875 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
H7R28_RS16535 3421945..3423273 - 1329 Protein_3240 diguanylate cyclase -
H7R28_RS16540 3423281..3425629 - 2349 WP_021523051.1 EAL domain-containing protein -
H7R28_RS16545 3425807..3426718 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-124)

Antitoxin

(53-94)


Sequences


Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T34371 WP_000539521.1 NZ_AP022069:3421170-3421556 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T34371 NZ_AP022069:3421170-3421556 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT34371 WP_001280945.1 NZ_AP022069:3421546-3421875 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT34371 NZ_AP022069:3421546-3421875 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829GCT6


Antitoxin

Source ID Structure

References