Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1473703..1474280 Replicon chromosome
Accession NZ_AP021972
Organism Klebsiella sp. WP3-W18-ESBL-02

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag H7R56_RS07015 Protein ID WP_106924165.1
Coordinates 1473703..1474032 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag H7R56_RS07020 Protein ID WP_106924166.1
Coordinates 1474029..1474280 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R56_RS06985 1469265..1470164 - 900 WP_106924159.1 oxygen-dependent coproporphyrinogen oxidase -
H7R56_RS06990 1470164..1471033 - 870 WP_106924160.1 N-acetylmuramoyl-L-alanine amidase AmiA -
H7R56_RS06995 1471247..1471672 + 426 WP_181357945.1 GNAT family acetyltransferase -
H7R56_RS07000 1471659..1472108 + 450 WP_106924162.1 DUF2919 domain-containing protein -
H7R56_RS07005 1472170..1472745 + 576 WP_106924163.1 RpoE-regulated lipoprotein -
H7R56_RS07010 1472843..1473742 + 900 WP_106924164.1 Dyp-type peroxidase -
H7R56_RS07015 1473703..1474032 - 330 WP_106924165.1 Txe/YoeB family addiction module toxin Toxin
H7R56_RS07020 1474029..1474280 - 252 WP_106924166.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H7R56_RS07025 1474527..1475543 + 1017 WP_106924167.1 sulfate ABC transporter substrate-binding protein -
H7R56_RS07030 1475543..1476376 + 834 WP_035897290.1 sulfate/thiosulfate ABC transporter permease CysT -
H7R56_RS07035 1476376..1477251 + 876 WP_106924168.1 sulfate/thiosulfate ABC transporter permease CysW -
H7R56_RS07040 1477241..1478335 + 1095 WP_106924169.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12730.57 Da        Isoelectric Point: 9.3653

>T33980 WP_106924165.1 NZ_AP021972:c1474032-1473703 [Klebsiella sp. WP3-W18-ESBL-02]
VKLIWSAQAWDDYLYWQDTDKSMIKKINELIREIKRTPFVGKGKPEPLKFDLAGFWSRRITLEHRLVYKLDNDALLVAAC
RYHHQTARFMASEENAPYNATNLSSEGAK

Download         Length: 330 bp

>T33980 NZ_AP021972:c1474032-1473703 [Klebsiella sp. WP3-W18-ESBL-02]
GTGAAACTTATCTGGTCAGCACAGGCATGGGACGATTATCTGTACTGGCAAGATACGGATAAGAGCATGATAAAAAAGAT
AAACGAGCTTATCAGGGAGATTAAACGCACGCCCTTTGTCGGCAAAGGTAAGCCAGAACCGCTGAAATTTGATCTGGCGG
GATTTTGGTCCCGCCGGATCACATTAGAGCATCGACTTGTCTACAAACTTGATAACGATGCTCTACTGGTTGCGGCATGC
CGGTATCACCATCAGACGGCCCGTTTTATGGCATCTGAAGAGAATGCACCTTACAACGCCACTAACTTATCCAGCGAAGG
CGCAAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9372.70 Da        Isoelectric Point: 4.8004

>AT33980 WP_106924166.1 NZ_AP021972:c1474280-1474029 [Klebsiella sp. WP3-W18-ESBL-02]
MRIISDSEARQNLSTTLRQATEDRAPIIITQQNGKACVLMSLEEYRSLEETAYLMRSPANAGRLMDAIEELKTGKGIQRD
LME

Download         Length: 252 bp

>AT33980 NZ_AP021972:c1474280-1474029 [Klebsiella sp. WP3-W18-ESBL-02]
ATGAGAATAATCAGCGATAGCGAAGCCCGGCAAAACCTATCCACAACGCTACGGCAAGCGACGGAAGACCGCGCCCCTAT
TATCATCACCCAACAAAACGGTAAGGCATGCGTGCTGATGTCGCTCGAAGAATACCGTTCGCTGGAAGAAACCGCTTATC
TGATGCGATCACCCGCAAATGCCGGACGACTCATGGATGCGATTGAGGAGCTAAAAACTGGAAAAGGTATCCAAAGGGAT
TTGATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References