Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1771420..1772251 Replicon chromosome
Accession NZ_AP021891
Organism Escherichia coli strain 2017.01.04CC

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag VEGS_RS08395 Protein ID WP_000854814.1
Coordinates 1771420..1771794 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag VEGS_RS08400 Protein ID WP_001285585.1
Coordinates 1771883..1772251 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VEGS_RS08355 1766816..1767982 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
VEGS_RS08360 1768101..1768574 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
VEGS_RS08365 1768772..1769830 + 1059 WP_001200891.1 FUSC family protein -
VEGS_RS08370 1770002..1770331 + 330 WP_000450409.1 DUF496 family protein -
VEGS_RS08375 1770432..1770614 - 183 WP_001016348.1 hypothetical protein -
VEGS_RS08380 1770686..1770814 + 129 Protein_1637 transposase domain-containing protein -
VEGS_RS08385 1771103..1771216 - 114 WP_001161660.1 DUF957 domain-containing protein -
VEGS_RS08390 1771229..1771423 - 195 WP_000988600.1 hypothetical protein -
VEGS_RS08395 1771420..1771794 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
VEGS_RS08400 1771883..1772251 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
VEGS_RS08405 1772325..1772546 - 222 WP_000692323.1 DUF987 domain-containing protein -
VEGS_RS08410 1772609..1773085 - 477 WP_001186773.1 RadC family protein -
VEGS_RS08415 1773101..1773580 - 480 WP_000860076.1 antirestriction protein -
VEGS_RS08420 1773662..1774483 - 822 WP_001234530.1 DUF945 domain-containing protein -
VEGS_RS08425 1774704..1775114 - 411 WP_000846713.1 hypothetical protein -
VEGS_RS08430 1775130..1775813 - 684 Protein_1647 hypothetical protein -
VEGS_RS08435 1775949..1777019 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T33552 WP_000854814.1 NZ_AP021891:c1771794-1771420 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T33552 NZ_AP021891:c1771794-1771420 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT33552 WP_001285585.1 NZ_AP021891:c1772251-1771883 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT33552 NZ_AP021891:c1772251-1771883 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References