Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 5136728..5137354 Replicon chromosome
Accession NZ_AP021876
Organism Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GN113_RS22365 Protein ID WP_155313817.1
Coordinates 5136728..5137018 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GN113_RS22370 Protein ID WP_155313818.1
Coordinates 5137028..5137354 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN113_RS22340 5132242..5133284 + 1043 Protein_4451 IS630 family transposase -
GN113_RS22345 5133841..5134032 - 192 WP_155324021.1 hypothetical protein -
GN113_RS22350 5134486..5134815 + 330 WP_173179721.1 DUF4258 domain-containing protein -
GN113_RS22355 5134812..5135027 + 216 WP_020587764.1 hypothetical protein -
GN113_RS22360 5135630..5136406 + 777 WP_155324022.1 hypothetical protein -
GN113_RS22365 5136728..5137018 + 291 WP_155313817.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GN113_RS22370 5137028..5137354 + 327 WP_155313818.1 putative addiction module antidote protein Antitoxin
GN113_RS22375 5137489..5137755 - 267 WP_155324023.1 type II toxin-antitoxin system RelE/ParE family toxin -
GN113_RS22380 5137752..5138003 - 252 WP_155322976.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GN113_RS22385 5138196..5138759 - 564 WP_155324024.1 hypothetical protein -
GN113_RS22390 5138936..5139073 - 138 WP_155311482.1 hypothetical protein -
GN113_RS22395 5139705..5141627 + 1923 WP_173179723.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-85)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10842.69 Da        Isoelectric Point: 10.7928

>T33434 WP_155313817.1 NZ_AP021876:5136728-5137018 [Desulfosarcina ovata subsp. sediminis]
MIEIRKTETFAKWLDGLNDIRARARILVRIERLAAGNPGDVKPVGEGVSELRIDYGPGYRVYYKKRGSKLIILLAGGDKR
TQSKDIKFALRLAQNL

Download         Length: 291 bp

>T33434 NZ_AP021876:5136728-5137018 [Desulfosarcina ovata subsp. sediminis]
ATGATCGAAATCCGTAAGACTGAGACTTTTGCCAAGTGGCTTGACGGTTTGAACGATATCCGTGCACGTGCTCGTATTTT
GGTAAGGATCGAACGGTTGGCAGCAGGTAATCCTGGTGATGTTAAACCTGTCGGCGAAGGAGTTTCAGAGTTACGTATCG
ACTACGGCCCAGGTTACCGCGTTTATTACAAAAAGCGAGGCAGCAAATTGATCATTCTATTGGCTGGTGGCGATAAGCGC
ACTCAATCCAAGGACATAAAATTCGCATTGCGCCTTGCTCAGAATCTATAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11662.34 Da        Isoelectric Point: 6.7186

>AT33434 WP_155313818.1 NZ_AP021876:5137028-5137354 [Desulfosarcina ovata subsp. sediminis]
MSKIITTRYDVAEHLRTPEEMAAYLEACFEEASGDAAFIAKALGDIARAKGMSQVARDAGLSRESLYKALSGERRPTFDT
ILKVIGALGLKLHAEAIHTNINTGQPVT

Download         Length: 327 bp

>AT33434 NZ_AP021876:5137028-5137354 [Desulfosarcina ovata subsp. sediminis]
ATGTCTAAAATCATCACAACACGCTACGATGTCGCTGAGCATCTTCGGACGCCGGAGGAAATGGCAGCCTATCTTGAAGC
TTGTTTCGAGGAGGCATCAGGTGATGCTGCTTTCATTGCCAAAGCCCTGGGTGATATCGCACGCGCAAAAGGCATGTCGC
AGGTGGCTCGTGATGCCGGACTTTCCAGAGAAAGTCTTTATAAAGCCCTGTCAGGAGAACGAAGGCCAACCTTCGATACA
ATTCTTAAGGTGATCGGAGCACTTGGCCTAAAATTGCATGCGGAAGCGATTCATACAAATATCAATACGGGCCAACCTGT
CACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References