Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/Phd-LOTUS_5_Limkain_b1
Location 218642..219363 Replicon plasmid pHC11
Accession NZ_AP019802
Organism Thermus thermophilus strain HC11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag TthHC11_RS11540 Protein ID WP_014630570.1
Coordinates 218642..218950 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag TthHC11_RS11545 Protein ID WP_162467455.1
Coordinates 218947..219363 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TthHC11_RS11520 215071..216240 + 1170 WP_143591963.1 cytochrome P450 -
TthHC11_RS11525 216237..216935 + 699 WP_011174499.1 lycopene cyclase domain-containing protein -
TthHC11_RS11530 216940..217617 + 678 WP_143591964.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
TthHC11_RS11535 217614..218636 + 1023 WP_011174497.1 glycosyltransferase -
TthHC11_RS11540 218642..218950 + 309 WP_014630570.1 type II toxin-antitoxin system Phd/YefM family antitoxin Toxin
TthHC11_RS11545 218947..219363 + 417 WP_162467455.1 type II toxin-antitoxin system VapC family toxin Antitoxin
TthHC11_RS11550 219461..221029 + 1569 WP_143591965.1 phytoene desaturase -
TthHC11_RS11555 221026..222024 + 999 WP_143591966.1 type 2 isopentenyl-diphosphate Delta-isomerase -
TthHC11_RS11560 222034..222426 + 393 WP_011174492.1 nucleotidyltransferase domain-containing protein -
TthHC11_RS11565 222457..223404 - 948 WP_143591967.1 DUF523 and DUF1722 domain-containing protein -
TthHC11_RS11570 223401..224189 - 789 WP_143591968.1 tryptophan-rich sensory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..258759 258759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(20-83)

Antitoxin

PIN domain

(3-129)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11640.40 Da        Isoelectric Point: 8.5043

>T33080 WP_014630570.1 NZ_AP019802:218642-218950 [Thermus thermophilus]
VASKLDRPVFSVYPEGVKAIWQLQEAKARFSEVVERALKGEPQLVLRRGKKAVVVLDWETYARLTGEEASVLEALRPPKT
LPNEEVEALFQRQKTGFREVDF

Download         Length: 309 bp

>T33080 NZ_AP019802:218642-218950 [Thermus thermophilus]
GTGGCCTCTAAACTAGACAGACCGGTCTTTTCCGTGTACCCTGAGGGGGTGAAGGCCATCTGGCAACTCCAAGAGGCCAA
AGCCCGCTTTTCCGAGGTGGTGGAGCGGGCCCTCAAGGGGGAGCCCCAGCTCGTCCTCCGGCGGGGTAAGAAGGCGGTGG
TGGTGCTGGACTGGGAGACCTACGCCCGGCTCACGGGGGAAGAGGCCTCGGTCCTCGAGGCCCTAAGACCCCCCAAGACC
CTCCCCAATGAGGAGGTGGAAGCCCTCTTCCAAAGGCAAAAGACGGGCTTCCGGGAGGTGGACTTCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15255.85 Da        Isoelectric Point: 10.4393

>AT33080 WP_162467455.1 NZ_AP019802:218947-219363 [Thermus thermophilus]
MRYLLDTNVVSEAVKRRPHPKVVAFLRHLKVGEAYLSALTLGELVQGVARAPEARRAILSRWLSGLKASFSGRILPLDAE
VMELWGELTGNAMREGKPLSPLDAMLAATALRHGLILATRNTEEFRHVPVPLVNPWEG

Download         Length: 417 bp

>AT33080 NZ_AP019802:218947-219363 [Thermus thermophilus]
CTGAGGTACCTGCTGGACACCAACGTGGTCTCCGAGGCCGTCAAGCGGCGGCCTCACCCCAAGGTGGTGGCCTTCCTGCG
CCACCTTAAAGTGGGGGAGGCGTACCTCTCCGCCCTCACCTTGGGCGAACTGGTCCAGGGGGTGGCCCGGGCCCCGGAGG
CCCGAAGGGCCATCCTCAGCCGATGGCTCTCGGGGCTGAAGGCGAGCTTCTCGGGGCGGATCCTTCCCCTGGACGCCGAG
GTGATGGAGCTCTGGGGCGAGCTCACCGGAAACGCCATGAGGGAGGGCAAGCCCCTCTCTCCCCTAGACGCCATGCTGGC
GGCCACGGCCCTGCGGCACGGCCTCATCCTGGCCACCCGGAACACCGAGGAGTTCCGCCACGTTCCCGTGCCCCTCGTGA
ACCCCTGGGAAGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References