Detailed information of TA system TA033077

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 503051..503703
• Replicon: chromosome
• Accession: NZ_AP019801
• Organism: Thermus thermophilus strain HC11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: TthHC11_RS02810
• Protein ID: WP_143590560.1
• Coordinates: 503051..503443 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q5SKZ1
• Locus tag: TthHC11_RS02815
• Protein ID: WP_011227983.1
• Coordinates: 503443..503703 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TthHC11_RS02775	498177..499619	-	1443	WP_060384671.1	2-phosphoglycerate kinase	-
TthHC11_RS02790	499905..500294	+	390	WP_011227977.1	NADH-quinone oxidoreductase subunit 15	-
TthHC11_RS02795	500291..500692	-	402	WP_143590553.1	PaaI family thioesterase	-
TthHC11_RS02800	500722..501840	-	1119	WP_143590556.1	radical SAM family heme chaperone HemW	-
TthHC11_RS02805	501846..503066	-	1221	WP_143590558.1	glycerate kinase	-
TthHC11_RS02810	503051..503443	-	393	WP_143590560.1	type II toxin-antitoxin system VapC family toxin	Toxin
TthHC11_RS02815	503443..503703	-	261	WP_011227983.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
TthHC11_RS02820	503736..504992	-	1257	WP_143590562.1	glycolate oxidase subunit GlcF	-
TthHC11_RS02825	504997..506040	-	1044	WP_024118968.1	FAD-binding protein	-
TthHC11_RS02830	506027..507409	-	1383	WP_143590564.1	FAD-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-85)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14694.85 Da
• Isoelectric Point: 6.4876

>T33077 WP_143590560.1 NZ_AP019801:c503443-503051 [Thermus thermophilus]
MVLDTSALLGILFREEGYEELLEQLRRTRPHKVAAPTLAEAGIVLGARLGFERVHLLFELLTELQAEIVPFTERHAREAI
SAYRRYGRGKHPAGLNFGDCLSYALARVEGEPLLYKGQDFDRTDLAWKPS

Nucleotide

• Length: 393 bp

>T33077 NZ_AP019801:c503443-503051 [Thermus thermophilus]
ATGGTGCTGGACACCTCCGCCCTCCTGGGCATTCTCTTCCGGGAAGAAGGGTACGAGGAGCTTCTGGAGCAACTCCGGCG
CACCCGCCCCCACAAGGTGGCCGCGCCCACCCTGGCCGAAGCGGGGATCGTCCTGGGCGCCCGGCTGGGCTTTGAGCGGG
TGCATCTTCTCTTTGAACTCCTAACCGAGCTCCAGGCCGAGATCGTGCCCTTCACCGAAAGGCATGCCCGGGAGGCCATC
TCCGCTTACCGGCGCTACGGGCGGGGCAAGCACCCCGCCGGGCTCAACTTTGGGGACTGCCTGAGCTACGCCCTGGCCCG
GGTGGAGGGGGAACCCCTCCTCTACAAGGGCCAGGACTTTGACCGGACGGACCTGGCGTGGAAGCCCTCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10086.61 Da
• Isoelectric Point: 5.0285

>AT33077 WP_011227983.1 NZ_AP019801:c503703-503443 [Thermus thermophilus]
MALTIRNKEVERLAEEVARLAGETKTEAVRKALEMRLRELQRKRSFDRVIRFLEEEVWPQIPPELLGKGLSKEEEEEILG
YGKEGY

Nucleotide

• Length: 261 bp

>AT33077 NZ_AP019801:c503703-503443 [Thermus thermophilus]
ATGGCCCTCACCATTCGCAACAAGGAGGTGGAGCGCCTGGCGGAGGAGGTGGCCCGCCTCGCCGGAGAAACCAAGACGGA
GGCCGTAAGGAAGGCCCTGGAGATGCGCCTTAGGGAACTCCAGAGGAAGCGGAGCTTTGACCGGGTGATCCGCTTCCTGG
AAGAGGAAGTCTGGCCCCAAATCCCGCCGGAGCTTTTGGGGAAGGGGCTCTCCAAGGAAGAGGAGGAAGAAATCCTGGGG
TACGGCAAGGAGGGGTACTGA

Structures

Antitoxin

• AlphaFold DB: A0A7R7YHV5