Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4059130..4059749 Replicon chromosome
Accession NZ_AP019665
Organism Klebsiella pneumoniae strain TA6363

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag TA6363_RS19910 Protein ID WP_002892050.1
Coordinates 4059531..4059749 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag TA6363_RS19905 Protein ID WP_002892066.1
Coordinates 4059130..4059504 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TA6363_RS19895 4054282..4055475 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
TA6363_RS19900 4055498..4058644 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
TA6363_RS19905 4059130..4059504 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
TA6363_RS19910 4059531..4059749 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
TA6363_RS19915 4059908..4060474 + 567 WP_002892030.1 maltose O-acetyltransferase -
TA6363_RS19920 4060446..4060586 - 141 WP_004147370.1 hypothetical protein -
TA6363_RS19925 4060607..4061077 + 471 WP_002892026.1 YlaC family protein -
TA6363_RS19930 4061052..4062503 - 1452 WP_004177237.1 PLP-dependent aminotransferase family protein -
TA6363_RS19935 4062604..4063302 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
TA6363_RS19940 4063299..4063439 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
TA6363_RS19945 4063439..4063702 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T32834 WP_002892050.1 NZ_AP019665:4059531-4059749 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T32834 NZ_AP019665:4059531-4059749 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT32834 WP_002892066.1 NZ_AP019665:4059130-4059504 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT32834 NZ_AP019665:4059130-4059504 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References