Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2442238..2442767 Replicon chromosome
Accession NZ_AP019306
Organism Staphylococcus aureus strain TUM9463

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag EKM74_RS12925 Protein ID WP_001103933.1
Coordinates 2442450..2442767 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag EKM74_RS12920 Protein ID WP_001058487.1
Coordinates 2442238..2442447 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKM74_RS12885 2438689..2439153 + 465 WP_001085183.1 SsrA-binding protein SmpB -
EKM74_RS12895 2439716..2440822 - 1107 WP_000121223.1 site-specific integrase -
EKM74_RS12900 2440828..2441475 - 648 WP_072474260.1 helix-turn-helix domain-containing protein -
EKM74_RS12905 2441633..2441839 + 207 WP_001060953.1 hypothetical protein -
EKM74_RS12910 2441875..2442102 + 228 WP_000164237.1 helix-turn-helix domain-containing protein -
EKM74_RS12915 2442099..2442245 + 147 WP_000784893.1 hypothetical protein -
EKM74_RS12920 2442238..2442447 + 210 WP_001058487.1 hypothetical protein Antitoxin
EKM74_RS12925 2442450..2442767 + 318 WP_001103933.1 DUF1474 family protein Toxin
EKM74_RS12930 2442834..2443703 + 870 WP_001002695.1 primase alpha helix C-terminal domain-containing protein -
EKM74_RS12935 2443720..2445189 + 1470 WP_001668899.1 virulence-associated E family protein -
EKM74_RS12945 2445475..2445837 + 363 WP_001039169.1 hypothetical protein -
EKM74_RS12950 2445839..2446123 + 285 WP_000998179.1 hypothetical protein -
EKM74_RS12955 2446120..2446761 + 642 WP_001019810.1 hypothetical protein -
EKM74_RS12960 2447211..2447552 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2436295..2459485 23190


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T32608 WP_001103933.1 NZ_AP019306:2442450-2442767 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T32608 NZ_AP019306:2442450-2442767 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT32608 WP_001058487.1 NZ_AP019306:2442238-2442447 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT32608 NZ_AP019306:2442238-2442447 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References