Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1611787..1612455 Replicon chromosome
Accession NZ_AP018937
Organism Streptococcus pneumoniae strain HU-OH

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag EL271_RS08675 Protein ID WP_001132284.1
Coordinates 1612276..1612455 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EL271_RS08670 Protein ID WP_000961810.1
Coordinates 1611787..1612239 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL271_RS08645 1607677..1608420 - 744 WP_001188199.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
EL271_RS08650 1608422..1609372 - 951 WP_000451132.1 50S ribosomal protein L11 methyltransferase -
EL271_RS08655 1609510..1609938 - 429 WP_000418176.1 NUDIX hydrolase -
EL271_RS08660 1609904..1611007 - 1104 WP_000719717.1 M50 family metallopeptidase -
EL271_RS08665 1611026..1611496 - 471 WP_000257106.1 DUF3013 family protein -
EL271_RS08670 1611787..1612239 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL271_RS08675 1612276..1612455 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
EL271_RS08680 1612592..1612771 - 180 WP_001809903.1 hypothetical protein -
EL271_RS08690 1612936..1613175 - 240 WP_000818078.1 hypothetical protein -
EL271_RS08700 1613445..1614716 + 1272 WP_001113196.1 replication-associated recombination protein A -
EL271_RS08710 1615261..1616580 - 1320 WP_000502545.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T32474 WP_001132284.1 NZ_AP018937:c1612455-1612276 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T32474 NZ_AP018937:c1612455-1612276 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT32474 WP_000961810.1 NZ_AP018937:c1612239-1611787 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT32474 NZ_AP018937:c1612239-1611787 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References