Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1553394..1554038 | Replicon | chromosome |
| Accession | NZ_AP018780 | ||
| Organism | Haemophilus influenzae strain CHBN-IV-1 isolate 13H36 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q4QKY0 |
| Locus tag | K6J73_RS07660 | Protein ID | WP_005643265.1 |
| Coordinates | 1553394..1553579 (+) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q4QKX9 |
| Locus tag | K6J73_RS07665 | Protein ID | WP_005692602.1 |
| Coordinates | 1553610..1554038 (+) | Length | 143 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J73_RS07625 (CHBNIV1_14480) | 1549102..1549992 | - | 891 | WP_050847652.1 | phage antirepressor N-terminal domain-containing protein | - |
| K6J73_RS07630 (CHBNIV1_14500) | 1550546..1550782 | - | 237 | WP_050847651.1 | hypothetical protein | - |
| K6J73_RS07635 (CHBNIV1_14510) | 1550803..1550994 | - | 192 | WP_050847650.1 | hypothetical protein | - |
| K6J73_RS07640 (CHBNIV1_14520) | 1551153..1551800 | + | 648 | WP_050847649.1 | hypothetical protein | - |
| K6J73_RS07645 (CHBNIV1_14530) | 1551874..1552599 | - | 726 | WP_221252938.1 | hypothetical protein | - |
| K6J73_RS07650 (CHBNIV1_14540) | 1552592..1552957 | - | 366 | WP_005672809.1 | RusA family crossover junction endodeoxyribonuclease | - |
| K6J73_RS07655 (CHBNIV1_14550) | 1552954..1553238 | - | 285 | WP_046950508.1 | DUF1364 domain-containing protein | - |
| K6J73_RS07660 | 1553394..1553579 | + | 186 | WP_005643265.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K6J73_RS07665 (CHBNIV1_14560) | 1553610..1554038 | + | 429 | WP_005692602.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K6J73_RS07670 (CHBNIV1_14570) | 1554039..1554548 | - | 510 | WP_005692600.1 | DUF1367 family protein | - |
| K6J73_RS07675 (CHBNIV1_14580) | 1554553..1555143 | - | 591 | WP_042600466.1 | DNA N-6-adenine-methyltransferase | - |
| K6J73_RS07680 (CHBNIV1_14590) | 1555140..1555775 | - | 636 | WP_112083855.1 | replication protein P | - |
| K6J73_RS07685 (CHBNIV1_14600) | 1555760..1556518 | - | 759 | WP_221252939.1 | helix-turn-helix domain-containing protein | - |
| K6J73_RS07690 (CHBNIV1_14610) | 1556515..1557189 | - | 675 | WP_038441201.1 | phage antirepressor KilAC domain-containing protein | - |
| K6J73_RS07695 (CHBNIV1_14620) | 1557238..1557678 | - | 441 | WP_005651303.1 | YmfL family putative regulatory protein | - |
| K6J73_RS07700 (CHBNIV1_14630) | 1557727..1557930 | - | 204 | WP_005651305.1 | YdaS family helix-turn-helix protein | - |
| K6J73_RS07705 (CHBNIV1_14640) | 1558052..1558807 | + | 756 | WP_005668731.1 | S24 family peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1511456..1574734 | 63278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6716.88 Da Isoelectric Point: 11.1595
>T32209 WP_005643265.1 NZ_AP018780:1553394-1553579 [Haemophilus influenzae]
MRSSDLIKELKSAGCTFVRHGKGDHQIWQSPITGKTFPVPHPKQHVPIGTLRSIKKSAGLL
MRSSDLIKELKSAGCTFVRHGKGDHQIWQSPITGKTFPVPHPKQHVPIGTLRSIKKSAGLL
Download Length: 186 bp
>T32209 NZ_AP018780:1553394-1553579 [Haemophilus influenzae]
ATGCGATCCAGCGACTTAATCAAGGAACTTAAAAGTGCAGGTTGTACTTTTGTCAGGCACGGTAAAGGCGATCATCAAAT
CTGGCAATCGCCCATCACAGGGAAGACGTTCCCCGTACCGCATCCAAAACAACACGTACCCATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTCTATAG
ATGCGATCCAGCGACTTAATCAAGGAACTTAAAAGTGCAGGTTGTACTTTTGTCAGGCACGGTAAAGGCGATCATCAAAT
CTGGCAATCGCCCATCACAGGGAAGACGTTCCCCGTACCGCATCCAAAACAACACGTACCCATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTCTATAG
Antitoxin
Download Length: 143 a.a. Molecular weight: 16458.45 Da Isoelectric Point: 4.3241
>AT32209 WP_005692602.1 NZ_AP018780:1553610-1554038 [Haemophilus influenzae]
MLFTIGIETPTNENEAYGITVPALFTEEYSCFSAADTLEEIPTQVTDAIHSILEMMFEDGIDINELQDKGYRHYQTQEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRQ
MLFTIGIETPTNENEAYGITVPALFTEEYSCFSAADTLEEIPTQVTDAIHSILEMMFEDGIDINELQDKGYRHYQTQEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRQ
Download Length: 429 bp
>AT32209 NZ_AP018780:1553610-1554038 [Haemophilus influenzae]
ATGTTATTCACTATCGGCATTGAAACCCCAACAAACGAAAATGAAGCCTACGGCATTACGGTGCCAGCATTATTTACTGA
AGAATATTCCTGCTTTAGTGCCGCTGATACCCTTGAGGAAATCCCAACGCAGGTGACTGATGCCATTCATTCCATCTTAG
AAATGATGTTTGAAGACGGAATAGACATCAACGAACTTCAAGATAAAGGCTATCGTCACTACCAAACGCAAGAAGATTTC
AACTATTGCGATACTTGGTTGTTGCTTGATGTAGATATTTCCGCATATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCTGAATACCTTATCAAACGTATTGATAGCCGTGTTGCAAGCAATCCAATCTACAAAGACCGCAGCCACTTTTTAGCGA
TTGCCTCACAAAAAGAGCTACGGCAATAA
ATGTTATTCACTATCGGCATTGAAACCCCAACAAACGAAAATGAAGCCTACGGCATTACGGTGCCAGCATTATTTACTGA
AGAATATTCCTGCTTTAGTGCCGCTGATACCCTTGAGGAAATCCCAACGCAGGTGACTGATGCCATTCATTCCATCTTAG
AAATGATGTTTGAAGACGGAATAGACATCAACGAACTTCAAGATAAAGGCTATCGTCACTACCAAACGCAAGAAGATTTC
AACTATTGCGATACTTGGTTGTTGCTTGATGTAGATATTTCCGCATATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCTGAATACCTTATCAAACGTATTGATAGCCGTGTTGCAAGCAATCCAATCTACAAAGACCGCAGCCACTTTTTAGCGA
TTGCCTCACAAAAAGAGCTACGGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|