Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1655407..1655996 Replicon chromosome
Accession NZ_AP018771
Organism Haemophilus influenzae strain CHBN-II-8 isolate 10H27

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag K6J66_RS08350 Protein ID WP_005653200.1
Coordinates 1655748..1655996 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag K6J66_RS08345 Protein ID WP_005653201.1
Coordinates 1655407..1655751 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J66_RS08330 (CHBNII8_15910) 1650634..1652028 - 1395 WP_038439957.1 sodium-coupled multidrug efflux MATE transporter HmrM -
K6J66_RS08335 (CHBNII8_15920) 1652072..1652686 + 615 WP_005647294.1 riboflavin synthase -
K6J66_RS08340 (CHBNII8_15930) 1652754..1655363 - 2610 WP_038439959.1 aminopeptidase N -
K6J66_RS08345 (CHBNII8_15940) 1655407..1655751 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J66_RS08350 (CHBNII8_15950) 1655748..1655996 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J66_RS08355 (CHBNII8_15960) 1656415..1656909 + 495 WP_005664624.1 5-(carboxyamino)imidazole ribonucleotide mutase -
K6J66_RS08360 (CHBNII8_15970) 1656979..1658067 + 1089 WP_038439960.1 5-(carboxyamino)imidazole ribonucleotide synthase -
K6J66_RS08365 (CHBNII8_15980) 1658207..1659397 + 1191 WP_038439961.1 amino acid aminotransferase -
K6J66_RS08370 (CHBNII8_15990) 1659502..1660128 - 627 WP_005671598.1 energy-coupling factor ABC transporter ATP-binding protein -
K6J66_RS08375 (CHBNII8_16000) 1660130..1660762 - 633 WP_032824077.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T32138 WP_005653200.1 NZ_AP018771:c1655996-1655748 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T32138 NZ_AP018771:c1655996-1655748 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCCCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT32138 WP_005653201.1 NZ_AP018771:c1655751-1655407 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT32138 NZ_AP018771:c1655751-1655407 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTATTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References