Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1211917..1212451 Replicon chromosome
Accession NZ_AP018768
Organism Haemophilus influenzae strain CHBN-II-5 isolate 13H40

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K6J56_RS05915 Protein ID WP_044364318.1
Coordinates 1212272..1212451 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A432
Locus tag K6J56_RS05910 Protein ID WP_013525736.1
Coordinates 1211917..1212192 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J56_RS05890 (CHBNII5_11080) 1207320..1209359 - 2040 WP_038441065.1 excinuclease ABC subunit UvrB -
K6J56_RS05900 (CHBNII5_11090) 1209975..1210943 - 969 WP_038441067.1 zinc transporter permease subunit ZevB -
K6J56_RS05905 (CHBNII5_11100) 1210946..1211566 - 621 WP_044364321.1 zinc transporter binding subunit ZevA -
K6J56_RS05910 (CHBNII5_11110) 1211917..1212192 + 276 WP_013525736.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J56_RS05915 (CHBNII5_11120) 1212272..1212451 + 180 WP_044364318.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J56_RS05920 (CHBNII5_11130) 1212546..1214216 + 1671 WP_221281841.1 energy-dependent translational throttle protein EttA -
K6J56_RS05925 (CHBNII5_11140) 1214278..1214619 + 342 WP_044364314.1 SirB2 family protein -
K6J56_RS05930 (CHBNII5_11150) 1214624..1216594 + 1971 WP_044364312.1 GNAT family N-acetyltransferase -
K6J56_RS05935 (CHBNII5_11160) 1216591..1216764 + 174 WP_005657572.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-58)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-81)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6883.07 Da        Isoelectric Point: 8.5134

>T32117 WP_044364318.1 NZ_AP018768:1212272-1212451 [Haemophilus influenzae]
MYCLLNSLPLPVKYKDHALTGNWKGWRDCHIKNDLVLIYKIVGDEIRLARLNTHSEIFG

Download         Length: 180 bp

>T32117 NZ_AP018768:1212272-1212451 [Haemophilus influenzae]
ATGTATTGTCTTTTGAATAGCTTACCATTGCCAGTAAAATATAAAGATCATGCTTTAACTGGCAATTGGAAAGGTTGGCG
AGATTGCCATATTAAGAATGATCTTGTGCTTATTTATAAAATTGTGGGGGATGAAATAAGATTAGCGCGTCTTAATACCC
ATTCAGAAATTTTTGGTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10259.81 Da        Isoelectric Point: 6.0646

>AT32117 WP_013525736.1 NZ_AP018768:1211917-1212192 [Haemophilus influenzae]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHGHEYKTLEE
FHQAMLAEMKS

Download         Length: 276 bp

>AT32117 NZ_AP018768:1211917-1212192 [Haemophilus influenzae]
ATGGCTGCAGTTAGCTTTCGAGTACCTGATGAAACCAAAAATATAGCGTTTGAAGTGATTAAAAGTTATGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCTGTATCATTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTGGATAATCATCATGGGCATGAATACAAAACATTGGAGGAA
TTTCATCAAGCTATGCTAGCGGAGATGAAATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R2R7

References