Detailed information of TA system TA032113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 323108..323712
• Replicon: chromosome
• Accession: NZ_AP018768
• Organism: Haemophilus influenzae strain CHBN-II-5 isolate 13H40

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K6J56_RS01590
• Protein ID: WP_044364610.1
• Coordinates: 323108..323416 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0Y7JSS2
• Locus tag: K6J56_RS01595
• Protein ID: WP_005661259.1
• Coordinates: 323416..323712 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J56_RS01580 (CHBNII5_02950)	318182..319480	-	1299	WP_006995277.1	trigger factor	-
K6J56_RS08860	319784..319915	+	132	Protein_298	PT domain-containing protein	-
K6J56_RS01585 (CHBNII5_02960)	319851..323051	+	3201	WP_221281854.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
K6J56_RS01590 (CHBNII5_02970)	323108..323416	-	309	WP_044364610.1	type II toxin-antitoxin system YafQ family toxin	Toxin
K6J56_RS01595 (CHBNII5_02980)	323416..323712	-	297	WP_005661259.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K6J56_RS01600 (CHBNII5_02990)	323832..324686	-	855	WP_038440397.1	DUF3298 domain-containing protein	-
K6J56_RS01605 (CHBNII5_03000)	324705..326564	-	1860	WP_044364613.1	selenocysteine-specific translation elongation factor	-
K6J56_RS01610 (CHBNII5_03010)	326561..327946	-	1386	WP_038440401.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-99)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11956.71 Da
• Isoelectric Point: 7.2386

>T32113 WP_044364610.1 NZ_AP018768:c323416-323108 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCYIQGDLVLIYQYV
IHDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T32113 NZ_AP018768:c323416-323108 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCTATATTCAAGGCGATTTGGTACTGATTTACCAATACGTT
ATACACGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11015.37 Da
• Isoelectric Point: 4.4297

>AT32113 WP_005661259.1 NZ_AP018768:c323712-323416 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT32113 NZ_AP018768:c323712-323416 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0Y7JSS2