Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1586739..1587328 Replicon chromosome
Accession NZ_AP018767
Organism Haemophilus influenzae strain CHBN-II-4 isolate 13H33

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag K6J55_RS07835 Protein ID WP_005653200.1
Coordinates 1587080..1587328 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag K6J55_RS07830 Protein ID WP_005653201.1
Coordinates 1586739..1587083 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J55_RS07815 (CHBNII4_14880) 1581962..1583356 - 1395 WP_048942651.1 sodium-coupled multidrug efflux MATE transporter HmrM -
K6J55_RS07820 (CHBNII4_14890) 1583400..1584014 + 615 WP_042599650.1 riboflavin synthase -
K6J55_RS07825 (CHBNII4_14900) 1584086..1586695 - 2610 WP_042593851.1 aminopeptidase N -
K6J55_RS07830 (CHBNII4_14910) 1586739..1587083 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J55_RS07835 (CHBNII4_14920) 1587080..1587328 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J55_RS07840 (CHBNII4_14930) 1587499..1587993 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
K6J55_RS07845 (CHBNII4_14940) 1588063..1589151 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
K6J55_RS07850 (CHBNII4_14950) 1589291..1590481 + 1191 WP_005657030.1 amino acid aminotransferase -
K6J55_RS07855 (CHBNII4_14960) 1590588..1591214 - 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
K6J55_RS07860 (CHBNII4_14970) 1591216..1591848 - 633 WP_005660550.1 energy-coupling factor transporter transmembrane component T -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T32111 WP_005653200.1 NZ_AP018767:c1587328-1587080 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T32111 NZ_AP018767:c1587328-1587080 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT32111 WP_005653201.1 NZ_AP018767:c1587083-1586739 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT32111 NZ_AP018767:c1587083-1586739 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References