Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 325852..326456 Replicon chromosome
Accession NZ_AP018767
Organism Haemophilus influenzae strain CHBN-II-4 isolate 13H33

Toxin (Protein)


Gene name relE Uniprot ID Q9S658
Locus tag K6J55_RS01610 Protein ID WP_042593918.1
Coordinates 325852..326160 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag K6J55_RS01615 Protein ID WP_005692346.1
Coordinates 326160..326456 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J55_RS01600 (CHBNII4_02980) 320999..322297 - 1299 WP_048940860.1 trigger factor -
K6J55_RS01605 (CHBNII4_02990) 322598..325795 + 3198 WP_105897604.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
K6J55_RS01610 (CHBNII4_03000) 325852..326160 - 309 WP_042593918.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J55_RS01615 (CHBNII4_03010) 326160..326456 - 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J55_RS01620 (CHBNII4_03020) 326576..327430 - 855 WP_048942490.1 DUF3298 domain-containing protein -
K6J55_RS01625 (CHBNII4_03030) 327449..329308 - 1860 WP_048942489.1 selenocysteine-specific translation elongation factor -
K6J55_RS01630 (CHBNII4_03040) 329305..330690 - 1386 WP_048942488.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-99)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11921.67 Da        Isoelectric Point: 7.2393

>T32105 WP_042593918.1 NZ_AP018767:c326160-325852 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T32105 NZ_AP018767:c326160-325852 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT32105 WP_005692346.1 NZ_AP018767:c326456-326160 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT32105 NZ_AP018767:c326456-326160 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9S658

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References