Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2796461..2797113 Replicon chromosome
Accession NZ_AP018034
Organism Mycobacterium tuberculosis strain HN-205

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag CPZ09_RS13550 Protein ID WP_003905869.1
Coordinates 2796688..2797113 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag CPZ09_RS13545 Protein ID WP_003412749.1
Coordinates 2796461..2796682 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ09_RS13530 2794701..2794907 - 207 WP_003899347.1 hypothetical protein -
CPZ09_RS13535 2795043..2795666 + 624 WP_003900858.1 TIGR00725 family protein -
CPZ09_RS13540 2795656..2796408 + 753 WP_003901416.1 hypothetical protein -
CPZ09_RS13545 2796461..2796682 + 222 WP_003412749.1 antitoxin Antitoxin
CPZ09_RS13550 2796688..2797113 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
CPZ09_RS13555 2797136..2798317 - 1182 WP_003905870.1 2-oxo acid dehydrogenase subunit E2 -
CPZ09_RS13560 2798314..2799360 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
CPZ09_RS13565 2799371..2800474 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
CPZ09_RS13570 2800733..2801554 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
CPZ09_RS13575 2801551..2802108 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T31550 WP_003905869.1 NZ_AP018034:2796688-2797113 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T31550 NZ_AP018034:2796688-2797113 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGCGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT31550 WP_003412749.1 NZ_AP018034:2796461-2796682 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT31550 NZ_AP018034:2796461-2796682 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References