Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2254276..2255195 Replicon chromosome
Accession NZ_AP018034
Organism Mycobacterium tuberculosis strain HN-205

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag CPZ09_RS10940 Protein ID WP_024753682.1
Coordinates 2254590..2255195 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag CPZ09_RS10935 Protein ID WP_003410124.1
Coordinates 2254276..2254581 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ09_RS10900 2249539..2249739 + 201 Protein_2065 hypothetical protein -
CPZ09_RS10910 2251095..2251472 + 378 Protein_2067 hypothetical protein -
CPZ09_RS10915 2251469..2252509 + 1041 WP_003410103.1 ImmA/IrrE family metallo-endopeptidase -
CPZ09_RS10920 2252751..2253470 + 720 WP_003410108.1 DUF433 domain-containing protein -
CPZ09_RS10925 2253460..2253876 + 417 WP_003410114.1 hypothetical protein -
CPZ09_RS10930 2253892..2254191 - 300 WP_003410120.1 hypothetical protein -
CPZ09_RS10935 2254276..2254581 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
CPZ09_RS10940 2254590..2255195 - 606 WP_024753682.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CPZ09_RS10945 2255220..2255579 - 360 WP_003410131.1 hypothetical protein -
CPZ09_RS10950 2255739..2256416 - 678 WP_003905725.1 hypothetical protein -
CPZ09_RS10955 2256368..2256604 - 237 WP_003410133.1 hypothetical protein -
CPZ09_RS10960 2256811..2257707 - 897 WP_003410136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22743.97 Da        Isoelectric Point: 7.6272

>T31546 WP_024753682.1 NZ_AP018034:c2255195-2254590 [Mycobacterium tuberculosis]
VNVPWENAHGGALYCLIRGNEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

>T31546 NZ_AP018034:c2255195-2254590 [Mycobacterium tuberculosis]
GTGAACGTTCCATGGGAGAACGCGCACGGCGGCGCACTGTACTGCCTCATACGTGGGAATGAATTCTCGGCCTGGCACAG
GCTACTGTTTCAACGGCCCGGGTGCGCAGAGTCCGTCCTCGCCTGCCGGCATTTCCTCGACGGTAGCCCCGTCGCCCGCT
GCTCTTACCCGGAGGAATATCACCCTTGTGTGATATCGCGTATCGCGCTACTCTGCGACTCTGTGGGGTGGACGGCGGAT
GTGGAGCGCATCTCCGCCTGGCTCAACGGCTTGGACCGAGAGACCTACGAATTGGTGTTCGCAGCTATCGAGGTTCTCGA
GGAAGAGGGCCCCGCACTTGGCTGTCCTCTGGTGGACACGGTGCGTGGGTCGCGCCACAAGAACATGAAGGAGCTGCGTC
CAGGATCACAAGGGCGGTCCGAGGTCCGCATTCTGTTCGCCTTCGACCCGGCGCGGCAGGCGATCATGCTGGCCGCCGGT
AACAAGGCCGGGCGGTGGACCCAGTGGTACGACGAGAAGATCAAAGCGGCCGATGAGATGTTTGCCGAACATCTCGCACA
GTTCGAGGACACGAAGCCAAAGAGGCGCAAGCGCAAGAAAGGGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT31546 WP_003410124.1 NZ_AP018034:c2254581-2254276 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp

>AT31546 NZ_AP018034:c2254581-2254276 [Mycobacterium tuberculosis]
ATGGCGATGACACTACGGGACATGGACGCCGTACGTCCCGTTAACCGGGAGGCGGTGGACCGGCACAAGGCACGAATGCG
CGATGAAGTGCGGGCGTTCCGGCTCCGGGAGCTGCGCGCGGCTCAGTCACTCACCCAGGTCCAGGTGGCTGCGCTGGCGC
ACATCCGGCAGAGCCGGGTATCCAGCATCGAGAACGGCGACATCGGCTCCGCACAGGTCAACACACTGCGCAAATACGTG
TCCGCTCTTGGCGGAGAACTGGATATCACCGTCCGCCTGGGAGATGAGACATTCACCCTGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7EWC
PDB 7EWD
PDB 7EWE
AlphaFold DB A0A7U4BV30

References