Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 751922..752610 Replicon chromosome
Accession NZ_AP018034
Organism Mycobacterium tuberculosis strain HN-205

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag CPZ09_RS03525 Protein ID WP_003403386.1
Coordinates 751922..752359 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag CPZ09_RS03530 Protein ID WP_003911263.1
Coordinates 752356..752610 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ09_RS03495 748173..749183 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
CPZ09_RS03500 749571..749954 - 384 WP_003403365.1 ribonuclease VapC6 -
CPZ09_RS03505 750049..750204 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
CPZ09_RS03510 750280..750996 - 717 WP_023644507.1 CPBP family intramembrane metalloprotease -
CPZ09_RS03515 751272..751580 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
CPZ09_RS03520 751567..751812 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
CPZ09_RS03525 751922..752359 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
CPZ09_RS03530 752356..752610 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
CPZ09_RS03535 752724..755087 + 2364 WP_003901895.1 arylsulfatase AtsD -
CPZ09_RS03540 755150..755476 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CPZ09_RS03545 755388..755726 + 339 WP_003403405.1 PIN domain-containing protein -
CPZ09_RS03550 755723..755896 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T31525 WP_003403386.1 NZ_AP018034:c752359-751922 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T31525 NZ_AP018034:c752359-751922 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT31525 WP_003911263.1 NZ_AP018034:c752610-752356 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT31525 NZ_AP018034:c752610-752356 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References