Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 323645..324231 Replicon chromosome
Accession NZ_AP014568
Organism Serpentinomonas raichei strain A1

Toxin (Protein)


Gene name parE Uniprot ID A0A060NGQ6
Locus tag SRAA_RS01470 Protein ID WP_029462154.1
Coordinates 323645..323944 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A060NKZ1
Locus tag SRAA_RS01475 Protein ID WP_029462153.1
Coordinates 323941..324231 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRAA_RS01450 318834..319283 + 450 WP_029462158.1 nuclear transport factor 2 family protein -
SRAA_RS01455 319316..320974 + 1659 WP_045530576.1 deoxyribodipyrimidine photo-lyase -
SRAA_RS12155 320989..321156 + 168 WP_197537852.1 DUF2256 domain-containing protein -
SRAA_RS01460 321216..322898 + 1683 WP_082039839.1 cryptochrome/photolyase family protein -
SRAA_RS01465 322915..323613 - 699 WP_045476214.1 SDR family NAD(P)-dependent oxidoreductase -
SRAA_RS01470 323645..323944 - 300 WP_029462154.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
SRAA_RS01475 323941..324231 - 291 WP_029462153.1 hypothetical protein Antitoxin
SRAA_RS01480 324337..324633 - 297 WP_029462152.1 type II toxin-antitoxin system RelE/ParE family toxin -
SRAA_RS01485 324635..324829 - 195 WP_029462151.1 hypothetical protein -
SRAA_RS01490 324920..325987 - 1068 WP_045530579.1 histidinol-phosphate transaminase -
SRAA_RS01495 326172..326759 + 588 WP_045530581.1 imidazoleglycerol-phosphate dehydratase HisB -
SRAA_RS01500 326782..327477 + 696 WP_045530583.1 imidazole glycerol phosphate synthase subunit HisH -
SRAA_RS01505 327529..328269 + 741 WP_045530585.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
SRAA_RS01510 328290..329096 + 807 WP_045530586.1 imidazole glycerol phosphate synthase subunit HisF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11296.93 Da        Isoelectric Point: 10.6066

>T30657 WP_029462154.1 NZ_AP014568:c323944-323645 [Serpentinomonas raichei]
MKLVWTRIASADRKAIREYIARDNPAAAVSLDEQFSEKARHLLDHPKLGRAGRVAGTRELVAHRHYLLVYDLEGDWVRVL
RVQHTARQWPNPAAQPPPA

Download         Length: 300 bp

>T30657 NZ_AP014568:c323944-323645 [Serpentinomonas raichei]
ATGAAGCTGGTCTGGACCAGAATAGCCAGCGCCGACCGCAAAGCCATCCGCGAATACATTGCGCGCGACAACCCCGCGGC
CGCCGTGTCCCTCGACGAGCAGTTTTCCGAAAAAGCCCGCCATCTGCTCGATCACCCCAAGCTGGGCCGCGCCGGGCGTG
TGGCCGGTACGCGCGAACTGGTGGCGCACCGCCACTACCTCTTGGTCTATGACCTGGAAGGCGACTGGGTGCGTGTGCTG
CGGGTGCAGCACACGGCGCGGCAATGGCCGAATCCGGCCGCGCAGCCTCCCCCAGCTTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10689.82 Da        Isoelectric Point: 4.8605

>AT30657 WP_029462153.1 NZ_AP014568:c324231-323941 [Serpentinomonas raichei]
MSEATFTFRVDEALKTEFSSAAKARDRSGAQLLRDFMREFVQQQQEAAARDAWFRQQVQIGLDSANAGHLVSAEEVEAEA
AAWREQTRRGLAGLTA

Download         Length: 291 bp

>AT30657 NZ_AP014568:c324231-323941 [Serpentinomonas raichei]
ATGAGCGAAGCCACGTTTACTTTCCGTGTCGATGAGGCCCTGAAAACCGAGTTCAGCAGCGCCGCCAAAGCGCGTGACCG
CAGCGGTGCGCAGTTGCTGCGCGACTTCATGCGCGAATTCGTGCAGCAGCAACAAGAGGCGGCGGCGCGCGACGCTTGGT
TTAGGCAGCAGGTGCAGATCGGGCTGGATTCGGCCAATGCCGGCCATTTGGTTTCGGCCGAGGAGGTGGAGGCCGAAGCC
GCTGCTTGGCGCGAACAAACGCGGCGCGGACTCGCGGGCTTGACTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NGQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A060NKZ1

References