Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1808817..1809454 Replicon chromosome
Accession NC_022356
Organism Haemophilus influenzae KR494

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A121YHB9
Locus tag HIFGL_RS08700 Protein ID WP_021035685.1
Coordinates 1808817..1809221 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag HIFGL_RS08705 Protein ID WP_005656316.1
Coordinates 1809218..1809454 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIFGL_RS08680 1805297..1805881 - 585 WP_021035682.1 primosomal replication protein -
HIFGL_RS08685 1805914..1807266 - 1353 WP_021035683.1 Na+/H+ antiporter family protein -
HIFGL_RS08690 1807580..1808269 - 690 WP_021035684.1 ribonuclease T -
HIFGL_RS08695 1808343..1808750 - 408 WP_005688980.1 lactoylglutathione lyase -
HIFGL_RS08700 1808817..1809221 - 405 WP_021035685.1 type II toxin-antitoxin system VapC family toxin Toxin
HIFGL_RS08705 1809218..1809454 - 237 WP_005656316.1 antitoxin Antitoxin
HIFGL_RS08710 1809547..1810272 - 726 WP_021035687.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
HIFGL_RS08715 1810326..1810844 - 519 WP_005688985.1 isoprenylcysteine carboxyl methyltransferase family protein -
HIFGL_RS08720 1811063..1812829 + 1767 WP_021035688.1 aspartate--tRNA ligase -
HIFGL_RS08725 1812851..1813327 + 477 WP_021035689.1 dihydroneopterin triphosphate diphosphatase -
HIFGL_RS08730 1813487..1814227 + 741 WP_005662961.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15690.26 Da        Isoelectric Point: 8.9777

>T30075 WP_021035685.1 NC_022356:c1809221-1808817 [Haemophilus influenzae KR494]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFSSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T30075 NC_022356:c1809221-1808817 [Haemophilus influenzae KR494]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTAGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT30075 WP_005656316.1 NC_022356:c1809454-1809218 [Haemophilus influenzae KR494]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT30075 NC_022356:c1809454-1809218 [Haemophilus influenzae KR494]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGATGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A121YHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References