Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 967053..967587 Replicon chromosome
Accession NC_022356
Organism Haemophilus influenzae KR494

Toxin (Protein)


Gene name relE Uniprot ID A0A2X4DRE9
Locus tag HIFGL_RS04715 Protein ID WP_041175309.1
Coordinates 967408..967587 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A112WVR2
Locus tag HIFGL_RS04710 Protein ID WP_021035051.1
Coordinates 967053..967328 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIFGL_RS04695 964287..964916 + 630 Protein_913 ESPR domain-containing protein -
HIFGL_RS04700 965104..966078 - 975 WP_021035049.1 zinc transporter permease subunit ZevB -
HIFGL_RS04705 966081..966701 - 621 WP_041175308.1 zinc transporter binding subunit ZevA -
HIFGL_RS04710 967053..967328 + 276 WP_021035051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HIFGL_RS04715 967408..967587 + 180 WP_041175309.1 type II toxin-antitoxin system YafQ family toxin Toxin
HIFGL_RS04720 967682..969352 + 1671 WP_041175310.1 energy-dependent translational throttle protein EttA -
HIFGL_RS04725 969414..969755 + 342 WP_021035054.1 SirB2 family protein -
HIFGL_RS04730 969760..971730 + 1971 WP_021035055.1 tRNA(Met) cytidine acetyltransferase TmcA -
HIFGL_RS09325 971727..971900 + 174 WP_021035056.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-58)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6913.05 Da        Isoelectric Point: 7.8827

>T30074 WP_041175309.1 NC_022356:967408-967587 [Haemophilus influenzae KR494]
MYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKIVGDEIRLARLNTHSEIFG

Download         Length: 180 bp

>T30074 NC_022356:967408-967587 [Haemophilus influenzae KR494]
ATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCACGCTTTAACTGGCAATTGGAAAGGTTGGCG
AGATTGCCATATTAAGAATGATCTCGTGCTTATTTATAAAATTGTGGGGGATGAAATAAGATTAGCGCGTCTTAATACCC
ATTCAGAAATTTTTGGTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10297.90 Da        Isoelectric Point: 5.6663

>AT30074 WP_021035051.1 NC_022356:967053-967328 [Haemophilus influenzae KR494]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHNGREYKTLEE
FHQAMLSEMKL

Download         Length: 276 bp

>AT30074 NC_022356:967053-967328 [Haemophilus influenzae KR494]
ATGGCTGCAGTTAGCTTTCGAGTACCTGATGAAACTAAAAATATAGCGTTTGAAGTGATTAAAAGTTATGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCATTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTGGATAATCATAATGGGCGTGAATACAAAACATTGGAGGAA
TTCCATCAAGCGATGCTATCGGAGATGAAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4DRE9

Antitoxin

Source ID Structure
AlphaFold DB A0A112WVR2

References